OBJECTIVE：To promote the working performace of automatic medicine packing machine in our hospital. METHODS： Combined with the problems we met in the use of the automatic medicine packing machine，the reconstructions of software functions，such as drug inventory management，drug identification，specific drug sub-package and document printing of non-package drug，were introduced. Related indicators were compared before and after reconstruction. RESULTS：After the software reconstruction， compared with 2012，loss events of expire drug due to poor sales fell by 70％ in 2013；drug dispensing errors related to medicine packing machine dropped by 1/2；the time of drug checking shortened by 1/5. CONCLUSIONS：The software program reconstruction of automatic medicine packing machine can improve the work efficiency of pharmacy and the accuracy of drug dispensing， further guarantee the quality and safety of drugs，and meet the practical demand of our hospital.