OBJECTIVE： To compare anesthesia and analgesia effect， safety of analgesia regimen among 4 kinds of painless induced abortion. METHODS： 200 women undergoing painless induced abortion were randomly divided into group A， B， C and D， with 50 cases in each group. They were given normal saline+propofol （group A）， fentanyl citrate+propofol （group B）， dezocine+propofol （group C）， flurbiprofen axetil+propofol （group D）， respectively. Lab indicator， anesthesia and analgesia effect and ADR were compared among 4 groups after treatment. RESULTS： Perioperative DBP and postoperative HR of group D were higher than those group A， and perioperative SpO2 was higher than group A， B and C， with statistical significance （P＜0.05）； the propofol dosage of group D and B was significantly less than group A and C， with statistical significance （P＜0.05）. The recovery time of group D was markedly less than group A， with statistical significance （P＜0.05）. VAS score of group D was significantly lower than that of group A and C， with statistical significance （P＜0.01 or P＜0.05）. The satisfactory degree of groups was better than group A， with statistical significance （P＜0.05）； the number of ADR cases in group D was less than other groups， with statistical significance （P＜0.05）. CONCLUSIONS： Flurbiprofen axetil has significant analgesic effect， which could reduce the dose of propofol， shorten the recovery time， and reduce the incidence of ADR in painless induced abortion， it is a safe and effective anesthesia regimen.