OBJECTIVE：To observe therapeutic efficacy and safety of tripterygium glycosides combined with valsartan in the treatment of idiopathic membranous nephropathy（IMN）. METHODS：A total of 85 patients with IMN were enrolled and randomly divided into observation group（42 cases）and control group（43 cases）. Based on routine treatment（reducing lipid，anti-platelet aggregation， protein dietary restriction），control group was additionally given oral valsartan，with initial dose of 80 mg/d，and gradually adding the amount to 160 mg/d if there was no obvious ADR；based on control group，observation group was additionally given Tripterygium glycosides tablet 40 mg，tid，and reducing the amount to 20 mg，tid after complete remission. 2 groups were treated for 12 months. RESULTS：Total effective rate of observation group was 92.86％，which was significantly higher than that of control group（74.42％），with statistical significance（P＜0.05）. Compared with before treatment，the levels of 24 h urine protein，TC and TG of 2 groups were decreased after treatment，and serum albumin（ALB）of observation group increased；24 h urine protein and TG of observation group was lower than control group，while the serum level of ALB was higher than control group，with statistical significance（P＜0.05 or P＜0.01）. No obvious ADR was found in 2 groups. CONCLUSIONS：Tripterygium glycosides combined with valsartan can improve the kidney function and blood lipid level of IMN patients with high safety.