OBJECTIVE: To investigate the compatibility stability of ozagrel sodium for injection with 3 kinds of injection containing fructose. METHODS: Ozagrel sodium for injection was mixed with 5% fructose injection, 5% fructose and sodium chloride injection and 5% calorose injection respectively, and then placed in constant temperature water bath at 25 ℃; 0,1,2,4,6 h later, the appearance and pH of mixture were observed and determined, and HPLC method was adopted to determine the content of ozagrel sodium in mixture. RESULTS: There was no significant changes in appearance, and pH ranged from 0.002 to 0.156, the content decreased from 100% to 95.7%within 6 hours after ozagrel sodium for injection mixed with 3 kinds of injection. CONCLUSIONS: After ozagrel sodium for injection mixed with 5% fructose injection, 5% fructose and sodium chloride injection and 5% calorose injection, the content of ozagrel sodium decrease gradually as times. In the practice, the mixture should be used up within 6 h.