OBJECTIVE：To establish the quality standards for Shenshuaikang granule. METHODS：TLC was used for the qualitative identification of Astragali Radix and Rhei Radix et Rhizoma in the preparation. HPLC was used for the contents determination of emodin and chrysophanol，the column was Agilent HC-C18 with mobile phase of methanol-0.1％ phosphoric acid（85 ∶ 15， V/V）at a flow rate of 1.0 ml/min，the detection wavelength was 254 nm，the column temperature was 30 ℃ and the injection volume was 10 μl. RESULTS：TLC showed clear spots and good separation. The linear range was 1.9-60.8 μg/ml for emodin（r＝0.999 9， n＝6）and 1.6-51.2 μg/ml for chrysophanol（r＝0.999 9），RSDs of precision，stability and reproducibility tests were lower than 3％，recoveries were 95.76％-103.66％（RSD＝2.83％，n＝9）and 97.24％-104.34％（RSD＝2.65％，n＝9），respectively. CONCLUSIONS： The standard can be used for the quality control of Shenshuaikang granule.