OBJECTIVE： To provide reference for dynamic adjustment of low-cost medicine lists and better guarantee of low-cost supply in those provinces，autonomous regions and municipalities[referred to provinces（autonomous regions or municipalities）]. METHODS： The varieties and frequency of medicines in the national and 31 province（autonomous regions or municipalities） lists were counted， and the influential factors were analyzed. RESULTS： The National Low-cost Medicine List included 533 varieties of medicines， including 283 western medicines， 250 Chinese patent medicines and 60 exclusive varieties. There were totally 973 varieties of medicines in the 31 province（autonomous regions or municipalities）， including 332 western medicines， 630 Chinese patent medicines， 11 ethnic medicines and 71 protected Chinese medicines. There was no big difference in the varieties between the eastern and western areas， and less in the central areas. Guangxi province had the largest number of selected medicines （345 varieties） and Jiangxi province had the smallest （10 varieties）. In all the varieties， Chinese medicines had a larger number than western medicines， and also better concentration. Ketotifen was the most frequent western medicine and Tongbianling capsule was the most frequent Chinese patent medicine， which appeared 30 and 29 times separately. The Provincial Low-cost Medicine Lists and the Essential Medicine Supplement Lists had a poor coincidence rate， and there was a moderate correlation between the varieties and the number of pharmaceutical manufacturers in the province（autonomous regions or municipalities）. CONCLUSIONS： The adjustment of low-cost medicine lists should be combined with these in province（autonomous regions or municipalities） nearby， and notice the linkage with national essential medicine system to fundamentally ensure the clinical medication requirements of patients.