OBJECTIVE：To prepare dexibuprofen sustained-release pellets，and to analyze the drug release behavior in vitro. METHODS：Centrifugal granulation powder layering-eudragit dispersion coating method was used to prepare dexibuprofen sustained- release pellets using 3％HPMC as adhesive agent. The formula of the pellets was optimized by orthogonal test with weight ratio of sucrose to dexibuprofen，weight ratio of HPMC to Eudragit NE30D and coating weight as factors，using 1，4 and 10 h accumulated release rate（Q）as index. The release of the drug from the pellets was analyzed. RESULTS：The optimized formulation was that the proportion of sucrose to drug was 1 ∶ 10，the weight ratio of HPMC to Eudragit NE30D was 1.5 ∶ 1，the increased weight of coating material was 8％. Q1 h，Q4 h and Q10 h of prepared pellets were 21％，57％ and 89％，respectively（n＝3）. The correlation coefficient of zero-order，one-order and Higuchi equation release model were 0.956 6，0.989 9，0.996 5. CONCLUSIONS： Prepared pellets show good sustained-release effect in vitro. Drug release of pellets is more in accordance with Higuchi equation.