OBJECTIVE： To investigate statin-induced  ADR in lipid-lowering therapy and the corresponding intervention strategies. METHODS： During Jan. 2013 to Jun. 2014， 2 106 patients receiving statin therapy for lowering lipid in our hospital were selected as subjects， involving 185 patients in ADR cases. Through medical records and basic data of all ADR patients were analyzed retrospectively， and the related risk factors were summarized and its targeted intervention countermeasures were studied. RESULTS： Among 185 cases of patients with ADR， there were 106  male patients （57.30％） and 79 female patients （42.70％）， with statistical significance （P＜0.05）； from the angle of patient’s age， over 50 years old was concentrated interval of statins-induced ADR， of which there were statistical significances in the incidence of ADR between 51-60 years old （63 cases， 34.05％）， 61-70 years old （56 cases， 41.48％） and other age groups  （P＜0.05）； according to ADR types， main clinical manifestations were digestive system reactions， liver toxicity and neurotoxicity reaction， with statistical significance compared with other types （P＜0.05）；  simvastatin and atorvastatin were the main factors leading ADR， there was statistical significance in the incidence of ADR compared with other drug types （P＜0.05）. CONCLUSIONS： This study indicates that the incidence of ADR are different among different gender， age and types of specific drugs. Lipid-lowering indications should be further mastered when statins is used for lipid-lowering therapy； drugs are selected carefully so as to relieve drug toxicity，  reduce the incidence of ADR and improve clinical therapeutic effect.