OBJECTIVE： To provide reference for further promoting the rational use of antimicrobial drugs in the rural community health service stations. METHODS： 4 800 prescriptions were collected from 8 community health service stations affiliated to our hospital from Jan. 1， 2012 to Dec. 31， 2014， the use of antimicrobial drugs in the prescriptions was statistically analyzed and the indicators were compared before and after intervention. RESULTS： The proportion of use of antimicrobial drugs in these community health service stations was decreased from 52.88％ in 2012 to 30.38％ in 2014； the clinical diagnosis of prescription of antimicrobial drug was mainly respiratory infections； what the most used types of antibacterial drugs was cephalosporins； and the proportion of antimicrobial drug of irrational use was decreased from 43.50％（368/846） in 2012 to 22.84％（111/486） in 2014. CONCLUSIONS： The combination of technique and administrative intervention is remarkable. However， the unreasonable use of antibacterial drugs still exists. Therefore， related training should be organized， and the proportion of use of antimicrobial drugs should included in the performance appraisal to further improve the use level of antimicrobial drugs in the rural community health service stations.