OBJECTIVE：To study the anti-inflammatory and analgesic effects of Zhuanggu shenjin capsule. METHODS：Each experiment took 65 rats，and the rats were randomly divided into model group（0.5％ sodium carboxymethylcellulose），Wantong jingu tablet group（reference drug，0.3 g/kg）and Zhuanggu shenjin capsule low-dose，medium-dose，and high-dose groups（0.3， 0.6，1.2 g/kg）. They were given relevant medicine intragastrically once a day for consecutive 7 days. Carrageenin paw swelling test and cotton ball granuloma test were adopted to determine the rate of paw swelling，cotton ball granuloma index and organ index. Each experiment took 55 mice，and the mice were randomly divided into model group（0.5％ sodium carboxymethylcellulose）， Wantong jingu tablet （reference drug，0.4 g/kg） and Zhuanggu shenjin capsule low-dose，medium-dose，and high-dose groups （0.4，0.8，1.6 g/kg）. They were given relevant medicine intragastrically once a day for consecutive 7 days. The permeabilities of blood capillary in abdominal cavity（by the content of azovanum caeruleum in abdominal cavity），twisting times and the percentage of pain threshold improvement were determined by the permeability test of blood capillary in abdominal cavity of mice，acetic acid twisting test and heat stimulation test. RESULTS：Compared with model group，the rate of paw swelling and cotton ball granuloma index of rats 2-6 h after inflammation induction decreased，and twisting times of mice also decreased while the percentage of pain threshold improvement in mice increased in Zhuanggu shenjin capsule medium-dose and high-dose groups（P＜0.05 or P＜ 0.01），but the permeabilities of blood capillary in abdominal cavity had no significant difference（P＞0.05）. CONCLUSIONS： Zhuanggu shenjin capsule has a good anti-inflammatory and analgesic effects.