OBJECTIVE：To provide reference for prescriptions audit before payment in hospital pharmacy. METHODS：The management measures of prescriptions audit and intervention before payment in our hospital were introduced. 1 200 outpatient prescriptions within 1 year before and after management were subjected to a statistical analysis. The effects of prescriptions audit before payment were evaluated through analyzing and comparing qualification rate of prescription and unqualified prescriptions. RESULTS： Our hospital adopted a series of measure to realize prescriptions audit and intervention before payment by clinical pharmacists， such as using information audit system，formulating audit standard，educating pharmacists，establishing audit job system， prescriptions review and feedback system，setting up communication system，etc. Of the total audited 189 665 prescriptions， 14 581（7.69％）failed to audit and 606 prescriptions hadn’t been revised after 1 year management，with effective intervention rate of 95.84％. Compared with before management，the prescription qualification rate increased from 88.83％ to 98.67％ after management（ P＜0.01）. The quantity of overdose，inconformity with medical insurance，overload and other conditions reduced to 0. CONCLUSIONS： It is feasible for pharmacists to audit and intervent prescriptions before payment in hospital pharmacy to improve prescription qualification and promote rational drug use in the clinic.