OBJECTIVE： To explore the role of clinical pharmacists on pharmaceutical care for allergic reaction caused by oxaliplatin. METHODS： Clinical pharmacists conducted pharmaceutical care for a patient with oxaliplatin-induced allergic reaction， and suggested stopping taking oxaliplatin， giving Dexamethasone injection 5 mg and then slowing down injection speed. RESULTS： Physicians adopted the suggestions of clinical pharmacists. Allergic reaction relieved 5 min after giving Dexamethasone injection. The patient didn’t suffered from this allergic reaction again under tight supervision. CONCLUSIONS： Oxaliplatin is often used for tumor therapy. Medical staff should be familiar with the prevention， diagnosis and treatment of ADR， evaluate oxaliplatin chemotherapy plan in advance and screen high risk allergy factor. The participation of clinical pharmacists in pharmaceutical care contribute to ADR monitoring and promote safe and rational drug use in the clinic.