OBJECTIVE： To provide reference for rational application of cephalosporins in the clinic. METHODS： The application of cephalosporins antibiotics in our hospital during 2010-2014 was analyzed dynamically in respects of consumption sum， DDD， DDC， DDDs， etc. RESULTS： During 2010-2014， the proportion of total consumption sum of antibiotics in total consumption sum kept below 30％， and decreased year by year， decreasing from 27.35％ in 2010 to 14.70％ in 2014. Among antibiotics， the consumption sum and DDDs of cephalosporins were the highest； consumption sum decreased year by year， decreasing from 44.50％ in 2010 to 30.49％ in 2014； DDDs increased year by year， increasing from 11.00×104 in 2012 to 14.22×104 in 2014. The consumption sum and DDDs of second generation cephalosporins were the highest. The consumption sum of cefotiam ranked the first place； DDDs of cefprozi ranked the first place during 2010-2011， while cefotiam ranked the first place during 2012-2014. DDC of cefpirome was the highest during 2010-2011， and that of cefamandole was the highest during 2012-2014， indicating it was expensive. The serial number ratio of cefprozi and cefuroxim was always ＞1 during those years， which indicated it was cheap and used frequently； that of most drugs were close to 1. CONCLUSIONS： The application of cephalosporins in our hospital tend to be rational， but  the propaganda and supervision of rational use of antibiotics should be further strengthened.