OBJECTIVE： To investigate the effects of different operation methods on the residual amount of docetaxel. METHODS： 60 Docetaxel injections were selected and divided into two groups， i.e. standard operation method was adopted in group A （30 injections）， and clinical common operation method was used in group B （30 injections）. Docetaxel injections were placed for 5， 10 or 15 minutes respectively， and drained. Residual liquid was collected to calculate residual amount. The difference of residual amount， due to preparation method and standing time， were compared between two groups. RESULTS： After placing for 5， 10 or 15 min， the volume and amount of residual liquid in group B were significantly higher than in group A （P＜0.05）. In same group， the volume and amount of residual liquid after placing for 10 and 15 min were all lower than that after placing for 5 min （P＜0.05 or P＜0.01）； the volume and amount of residual liquid after placing for 15 min were lower than that after placing for 10 min （P＜0.05）. CONCLUSIONS： The standard operation of pharmacy dispensing staff is very important to reduce the residual amount of docetaxel， and guarantee safe， effective and sufficient medication. It is suggested that clinical staff should abide by standard operation method.