OBJECTIVE：To study the impacts of Zishenyutai pills on the ovarian tissue oxidative damage and Nrf2 protein expression in rats exposed by electromagnetic radiation（EMR）. METHODS：Accordiny to their weight，30 SD rats were randomly divided into normal group，radiated group and radiated-treated group with 10 rats in each group. Normal group were not radiated， and other 2 groups were exposed by 900 MHz radiation for 4 h every day；radiated-treated group was given Zishenyutai pills suspension [0.25 g intragstrically（medicinal materials）/ml] after radiation；normal group and radiated group were given constant volume of normal saline intragastrically for consecutive 20 d. The rats were killed when they were at the estrum. The Nrf2 proteins expression of ovary were detected by immunohistochemical method，the content of ovary MDA（malondialdehyde），and activity of total superoxide dismutase（T-SOD）and superoxide dismutase（GSH-Px）were detected by biochemical method. RESULTS：Compared with the rats in normal group，the Nrf2 protein expression was higher in the rats of the radiated group；the content of ovary MDA was higher and activity of ovary T-SOD and GSH-Px were lower significantly（P＜0.05）. While compared with the rats in radiated group，the Nrf2 protein expression didn’t obviously change in the rats of the radiated-treated group（P＞0.05），the content of ovary MDA was lower and activity of ovary T-SOD and GSH-Px were higher significantly（P＜0.05）. CONCLUSIONS：Zishenyutai pills can prevent and cure ovary tissue oxidative injury induced by 900 MHz radiation，but have no effect on the expression of Nrf2 protein.