OBJECTIVE： To learn the application and tendency of hepatoprotective drugs in a third grade class A hospital during 2011-2014， and to provide reference for rational drug use. METHODS： DDDs analysis and consumption ordering method were adopted to analyze the change of DDDs， DDC and other index of hepatoprotective drugs in this hospital from 2011 to 2014. RESULTS： 2011-2014， the amount and DDDs of Hepatoprotective injection in this hospital increased year by year， while oral dosage form decreased year by year. DDC order of each drug kept stable during 2011-2014； DDC and DDDs of drugs for promoting energy metabolism were all in high level， and ornithine aspartate and ademetionine always took up the first 2 places in 4 years. Polyene phosphatidylcholine and Reduced glutathione injection were cheap， but had higher DDDs. Except Glutathione tablet， DUI of other hepatoprotective drugs had no great difference in 3 years， and fluctuated in 2014； hepatoprotective drugs with DUI＞1 and DUI＜1 occupied a large proportion. From 2010 to 2014， compared with previous year， the drugs with consumption sum/DDDs ratio number close to 1 reduced significantly in the next year， decreasing year by year. CONCLUSIONS： In this hospital， injections are used too frequently， and overuse of drugs for promoting energy metabolism exist. Polyene phosphatidylcholine and Reduced glutathione injection can be used as a valuable drug in the clinic， and their cost are more acceptable， but not in excess.