OBJECTIVE：To investigate the bacteriological characteristics of nasal secretions of chronic rhinosinusitis（CRS）in our hospital，and conduct drug sensitivity test in order to provide theoretic reference for clinical treatment. METHODS：87 CRS patients underwent nasal endoscopic surgery were selected and the nasal secretions of patients were taken for bacterial culture. Automatic microbial analyzer was used to identify the bacteriological characteristics，and disk diffusion test was adopted for drug sensitivity test. RESULTS：Of 87 patients，bacterial strains were detected from 77 cases of nasal secretions，with positive rate of 88.5％ . 112 strains were detected，including 81 strains of aerobic bacterium and 31 strains of anaerobic bacterium，and the most common bacterium were Staphylococcus aureus （20.54％）. Antibiotics with the highest sensitivity was moxifloxacin （89.29％）， followed by ciprofloxacin（87.50％），vancomycin（87.50％）. CONCLUSIONS：The bacterial in nasal secretions of CRS patients has high positive detection rate and mainly are aerobic bacterium. Antibiotics should be used rationally according to the results of drug sensitivity test.