OBJECTIVE：To systemically review the efficacy and safety of Ambroxol hydrochloride injection by intravenous drip combined with aerosol inhalation in the treatment of neonatal pneumonia，and provide evidence-based reference for the clinical treatment. METHODS：Retrieved from PubMed，Medline，CBM，CJFD，VIP and Wanfang Database，randomized controlled trials （RCT）about Ambroxol hydrochloride injection by intravenous drip combined with aerosol inhalation（test group）versus Ambroxol hydrochloride injection alone（control group）in the treatment of neonatal pneumonia. Meta-analysis was performed by using Rev Man 5.2 software after data extracting and quality evaluating by Cochrane 5.1.0. RESULTS：Totally 14 RCTs were enrolled，involving 1 407 patients. Results of Meta-analysis showed the clinical efficacy[RR＝1.19，95％ CI（1.13，1.24），P＜0.001] in test group was significantly higher than control group，the time of cough disappearance[MD＝－1.75，95％CI（－1.91，－1.58），P＜0.001]， asthma disappearance[MD＝－1.38，95％CI（－1.67，－1.08），P＜0.001] and pulmonary rales disappearance [MD＝－1.44，95％CI （－1.77，－1.11），P＜0.001] and hospitalization days[MD＝－2.04，95％CI（－2.25，－1.82），P＜0.001] were significantly shorter than control group，the differences were statistically significant；and there was no significant difference in the incidence of adverse reactions between 2 groups[RR＝1.00，95％CI（0.49，2.05），P＝1.00]. CONCLUSIONS：Both the efficacy and safety of Ambroxol hydrochloride injection by intravenous drip combined with aerosol inhalation are good in the treatment of neonatal pneumonia.