OBJECTIVE：To study the anti-inflammatory effects of Fengshi qutong capsule. METHODS：Each experiment took 60 rats，and then the rats were randomly divided into model（0.5％ sodium carboxymethylcellulose）group，Wantong jingu tablet group（reference drug，0.3 g/kg）and Fengshi qutong capsule low-dose，medium-dose and high-dose groups（0.25，0.5，1.0 g/kg）； they were given relevant medicine intragastrically once a day for consecutive 7 days. The rate of paw swelling，cotton ball granuloma index and organ index in rats were determined by carrageenin paw swelling test and cotton ball granuloma test. 60 mice were randomly divided into model group（0.5％ sodium carboxymethylcellulose），Wantong jingu tablet group（reference drug，0.4 g/kg） and Fengshi qutong capsule low-dose，medium-dose and high-dose groups（0.3，0.6，1.2 g/kg）；they were given relevant medicine intragastrically once a day for consecutive 7 days. The content of Evan’s blue in abdominal cavity was determined to investigate the permeabilities of blood capillary in abdominal cavity of mice. RESULTS：Compared with model group，the rate of paw swelling and cotton ball granuloma index in rats of Fengshi qutong capsule medium-dose and high-dose groups decreased significantly 1-6 h after inflammation induction（P＜0.05 or P＜0.01）；the permeability of blood capillary in abdominal cavity of the mice had no significant change in treatment groups（P＞0.05）；compared with Wantong jingu tablet group，there was no significant difference in each indicator of treatment groups（P＞0.05）. CONCLUSIONS：Fengshi qutong capsule has certain anti-inflammatory effects.