OBJECTIVE：To establish the HPLC fingerprints for Dangua yangmu cream. METHODS：HPLC was performed on the column of Kromasil C18 with mobile phase of acetonitrile-0.026％ phosphoric（gradient elution）at flow rate of 0.8 ml/min，the detection wavelength was 270 nm，the column temperature was 25 ℃ and the injection volume was 20 μ l. The chromatographic peak of aurantio-obtusin was used as reference peak to determine the 10 batches of Dangua yangmu cream，and Similarity Evaluation System for Chromatographic Fingerprint of TCM（version 2.0）was conducted to identify common peaks and evaluate similarity. RESULTS：There were totally 25 common peaks in the 10 batches of Dangua yangmu cream，and the similarity was not lower than 0.921. The validation results showed the fingerprints of 10 batches of Dangua yangmu cream had good consistency with the reference fingerprints. COMCLUSIONS：The established method is specific and reliable，and can provide basis for the quality evaluation and control of Dangua yangmu cream.