OBJECTIVE: To provide reference for the formulation of correct antifungal treatment strategy, and to promote standard use of antifungal agent. METHODS: A retrospective survey was conducted for 138 haematologic patients from May 2013 to May 2014 in a third grade class A hospital, of whom all had used antifungal drugs during hospitalization. We collected all patients’ information and analyzed it statistically. RESULTS: Of 138 haematologic patients, 3 were proven IFD (all were Candida infection), 6 were probable IFD, 12 were possible IFD, and 117 were undefined IFD. The positive rates of fungi pathogenic detection, fungal smear, G-test, and GM-test were 15.3%, 9.4%, 6.4% and 23.4% respectively. 6 kinds of antifungal were used, and voriconazole had the highest frequency, followed by fluconazole, itraconazole, amphotericin B, caspofungin and micafungin. 62.3% patients used only one kind of antifungal, but 15.9% patients used 2 or more kinds of antifungal. The average medication course was 20.5 days (1 day to 125 days). Irrational drug use showed improper drug selection, unreasonable dose, and replacing antifungal with insufficient basis. CONCLUSIONS: The antifungal use in haematologic patients in the hospital is consistent with the requirements of guidelines, but there are still some issues as insufficient antifurgal drug treatment course to be further standardized.
关键词
侵袭性真菌病抗真菌药物血液病合理用药
Keywords
Invasive fungal infectionAntifungal drugsBlood diseaseRational drug use