OBJECTIVE：To provide reference for rational use of drugs in patients with mental disorders. METHODS：In retrospective investigation，47 386 prescriptions of psychiatric department in our hospital during Sept. 2013 to Aug. 2014 were analyzed statistically. RESULTS：Totally 39 496 cases were enrolled in the 47 386 prescriptions. The median age of patients was 31.42，with male to female ratio of 1 ∶1.07；they were diagnosed as schizophrenia and other mental disorder，accounting for 65.34％，and followed by mood disorders，accounting for 15.20％ . They were mainly given single drug and two-drug use，accounting for 30.80％ and 61.68％ respectively. Clozapine，quetiapine，risperidone were top 3 prescription drugs in the list of frequency；olanzapine，quetiapine， risperidone were top 3 drug in the list of consumption sum. Among top 20 psychiatric prescription drugs，there were 7 kinds of drugs for schizophrenia and other psychiatric disorders，3 kinds of drugs for mood disorders. CONCLUSIONS：The use of antipsychotic drugs in our hospital is rational basically.