OBJECTIVE： To provide reference for rational drug use in leprosy patients. METHODS： We counted and analyzed the age and gender of the patients， prescription amount， the diagnosis， the usage of higher rates of use of antibacterials and NSAIDs drugs of 2 692 prescriptions in pharmacy of hanzhong sanatorium from January 2013 to September 2014.  RESULTS： Among 2 155 patients， the patients aged ≥61 accounted for 68.08％ and males accounted for 75.27％. The average amount of prescription was 20.02 yuan. The top three diseases were leprosy ulcers， upper respiratory tract infection and leprosy ophthalmopathy. The utilization rate of antimicrobial were 37.03％. The utilization rates of NSAIDs for joint damage， leprosy ulcers and leprosy ophthalmopathy which were all caused by Bacillus leprae were 94.26％（115/122）， 42.25％（169/400） and 16.73％（45/269）， respectively. CONCLUSIONS： There is a certain abuse of antibacterials. It’s suggested to stiengthen spreading of antibacterial knownledge，  and physicians should choose NSAIDs with definite efficacy and less ADR based on the characteristics of long-term drug use.