巨噬细胞膜仿生纳米递药系统在疾病靶向治疗中的应用

李婵莲; 宋佳敏; 陈美玲; 任晓亮; 王萌

doi:10.6039/j.issn.1001-0408.2022.18.23

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巨噬细胞膜仿生纳米递药系统在疾病靶向治疗中的应用

综述 | 更新时间：2023-02-22

- 巨噬细胞膜仿生纳米递药系统在疾病靶向治疗中的应用
- Application of biomimetic nano drug delivery system of macrophage membrane in disease targeted therapy
- 中国药房 2022年33卷第18期页码：2290-2294
- 作者机构：
  
  1.天津中医药大学组分中药国家重点实验室，天津　301617
  2.天津中医药大学中药学院，天津　301617
- 作者简介：
  
  硕士研究生。研究方向：纳米制剂的制备与研究。E-mail：chanlian108@163.com
  研究员，博士生导师，博士。研究方向：中药生物药剂学和中药制剂稳定性。E-mail：mengwangr@163.com
- 基金信息：
  
  Δ 基金项目国家自然科学基金面上项目(81873191)
- DOI：10.6039/j.issn.1001-0408.2022.18.23
  中图分类号： R943
- 纸质出版日期：2022-09-30，
  
  收稿日期：2022-03-05，
  
  修回日期：2022-08-09，
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李婵莲,宋佳敏,陈美玲等.巨噬细胞膜仿生纳米递药系统在疾病靶向治疗中的应用 ^Δ[J].中国药房,2022,33(18):2290-2294.

LI Chanlian,SONG Jiamin,CHEN Meiling,et al.Application of biomimetic nano drug delivery system of macrophage membrane in disease targeted therapy[J].ZHONGGUO YAOFANG,2022,33(18):2290-2294.
李婵莲,宋佳敏,陈美玲等.巨噬细胞膜仿生纳米递药系统在疾病靶向治疗中的应用 ^Δ[J].中国药房,2022,33(18):2290-2294. DOI： 10.6039/j.issn.1001-0408.2022.18.23.

LI Chanlian,SONG Jiamin,CHEN Meiling,et al.Application of biomimetic nano drug delivery system of macrophage membrane in disease targeted therapy[J].ZHONGGUO YAOFANG,2022,33(18):2290-2294. DOI： 10.6039/j.issn.1001-0408.2022.18.23.

摘要

近年来，基于细胞膜包裹纳米粒的仿生纳米递药系统发展迅速，在多种疾病中表现出比传统纳米递药系统更高的生物相容性及疗效。巨噬细胞作为免疫系统的成员，与多种疾病的发生、发展息息相关。巨噬细胞源自单核细胞，受到相应刺激后，可极化为M1型和M2型：M1型巨噬细胞参与促炎反应，M2型巨噬细胞参与抗炎反应。本文综述了近年来巨噬细胞膜包裹纳米粒的仿生纳米制剂在疾病靶向治疗中的应用现状，结果显示，巨噬细胞膜包裹纳米粒的仿生纳米制剂在恶性肿瘤（乳腺癌、结直肠癌、黑色素瘤、脑胶质瘤）、阿尔茨海默病、肝脏缺血再灌注损伤、动脉粥样硬化等治疗中都显现出了高靶向性和低免疫原性，但目前集中于抗肿瘤研究，且都处于实验室研究阶段。

Abstract

In recent years， biomimetic nanodelivery system based on cell membrane coating has developed rapidly and shows better biocompatibility and efficacy than traditional nanodelivery systems in a variety of diseases. Macrophages， as members of the immune system， are closely related to the occurrence and development of a variety of diseases. Macrophages are derived from monocytes and can be polarized into M1 and M2 types after corresponding stimulation： M1 macrophages involved in the proinflammatory reaction and M2 macrophages involved in the inflammatory reaction. This paper reviews the application status of biomimetic nanoparticles coated with macrophage membrane in disease targeted therapy in recent years. Biomimetic nanoparticles coated with macrophage membrane has shown its high targeting and low immunogenicity in the treatment of malignant tumors （breast cancer， colorectal cancer， melanoma， glioma）， Alzheimer’s disease， liver ischemia-reperfusion injury， atherosclerosis and so on. However， the research of Biomimetic nanoparticles coated with macrophage membrane currently focuses on anti-tumor research and is still in the laboratory research stage.

关键词

巨噬细胞细胞膜包裹纳米粒膜仿生纳米递药系统靶向治疗

Keywords

nanoparticles coated with cell membranebiomimetic delivery systemtargeted therapy

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