平行人工膜渗透模型在经皮给药系统药物渗透性筛选中的应用进展

宋三孔; 白银亮; 梁建娣

doi:10.6039/j.issn.1001-0408.2023.04.23

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平行人工膜渗透模型在经皮给药系统药物渗透性筛选中的应用进展

综述 | 更新时间：2023-02-24

- 平行人工膜渗透模型在经皮给药系统药物渗透性筛选中的应用进展
- Application progress of parallel artificial membrane permeation assay model in drug permeability screening of transdermal drug delivery system
- 中国药房 2023年34卷第4期页码：502-507
- 作者机构：
  
  兰州大学第二医院药剂科，兰州　730030
- 作者简介：
  
  主管药师，硕士。研究方向：药物新剂型、临床药学。E-mail：sosako@163.com
  主管药师，硕士。研究方向：中药有效成分的分离和质量控制。E-mail：350938357@qq.com
- 基金信息：
  
  甘肃省科技计划项目(20JR5RA313)
- DOI：10.6039/j.issn.1001-0408.2023.04.23
  中图分类号： R943
- 纸质出版日期：2023-02-28，
  
  收稿日期：2022-09-20，
  
  修回日期：2023-01-09，
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宋三孔,白银亮,梁建娣.平行人工膜渗透模型在经皮给药系统药物渗透性筛选中的应用进展 ^Δ[J].中国药房,2023,34(04):502-507.

SONG Sankong,BAI Yinliang,LIANG Jiandi.Application progress of parallel artificial membrane permeation assay model in drug permeability screening of transdermal drug delivery system[J].ZHONGGUO YAOFANG,2023,34(04):502-507.
宋三孔,白银亮,梁建娣.平行人工膜渗透模型在经皮给药系统药物渗透性筛选中的应用进展 ^Δ[J].中国药房,2023,34(04):502-507. DOI： 10.6039/j.issn.1001-0408.2023.04.23.

SONG Sankong,BAI Yinliang,LIANG Jiandi.Application progress of parallel artificial membrane permeation assay model in drug permeability screening of transdermal drug delivery system[J].ZHONGGUO YAOFANG,2023,34(04):502-507. DOI： 10.6039/j.issn.1001-0408.2023.04.23.

摘要

传统的Franz扩散池法一直是评价经皮给药系统（TDDS）药物渗透性的“金标准”，但在大量药物分子的高通量筛选方面，其存在效率低、成本高、离体皮肤不易获得、可靠性差、工作量大等缺点。平行人工膜渗透（PAMPA）模型的出现，为现有TDDS药物渗透性的评价提供了可靠的前期预测数据。PAMPA模型现已广泛应用于镇痛药、局部麻醉药、抗氧剂、解热镇痛抗炎药、维生素类、胆碱酯酶抑制剂、天然产物活性成分等TDDS药物及其制剂的渗透性筛选研究，具有可靠性高、重复性好、效率高、成本低、数据稳定等特点。PAMPA模型极大地提高了TDDS药物渗透性的高通量筛选效率，随着该模型的大量应用和逐步成熟，该模型将成为传统评价模型之外的一种新型有效的评价方法。

Abstract

The traditional model Franz diffusion cell method has always been the “gold standard” for evaluating the permeability of transdermal drug delivery system （TDDS） drug. However， in the high throughput screening of a large number of drug molecules， it has the disadvantages of low efficiency， high cost， difficulty to obtain isolated skin，poor reliability and large workload. The emergence of parallel artificial membrane permeation assay （PAMPA） model provides reliable pre-prediction data for the evaluation of permeability of TDDS drug. PAMPA model has been widely used in the permeability screening research of TDDS drugs and their preparations such as analgesics， local anesthetics， antioxidants， antipyretics， analgesics and anti-inflammatory drugs， vitamins， cholinesterase inhibitors， active ingredients of natural products， and has the characteristics of high reliability， good selectivity， high efficiency， low cost and data stability. PAMPA model has greatly improved the high throughput screening efficiency of TDDS drug permeability. With the extensive application and gradual maturity of this model， it will become a new and effective evaluation method in addition to the traditional evaluation model.

关键词

经皮给药系统平行人工膜渗透药物渗透性筛选

Keywords

parallel artificial membrane permeation assaydrug penetration screening

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