水飞蓟宾防治糖尿病及其并发症的作用机制研究进展

梁梦秋; 李磊; 孟艳秋; 汪海峰; 张志鹏; 高国铸

doi:10.6039/j.issn.1001-0408.2023.07.23

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水飞蓟宾防治糖尿病及其并发症的作用机制研究进展

综述 | 更新时间：2024-02-19

- 水飞蓟宾防治糖尿病及其并发症的作用机制研究进展
- Research progress on the mechanism of silibinin in preventing and treating diabetes and its complications
- 中国药房 2023年34卷第7期页码：887-891
- 作者机构：
  
  沈阳化工大学制药与生物工程学院，沈阳　110142
- 作者简介：
  
  硕士研究生。研究方向：天然产物的生物活性及其剂型研发。E-mail：806751456@qq.com
  副教授，硕士生导师。研究方向：药物新剂型及药用新辅料的研发。E-mail：lilei@syuct.edu.cn
- 基金信息：
  
  辽宁省教育厅基本科研项目(LJKMZ20220784);辽宁省教育厅科学研究经费项目（面上项目）(LJKZ0427);辽宁省教育厅科学研究经费项目(LQ2020021)
- DOI：10.6039/j.issn.1001-0408.2023.07.23
  中图分类号： R965;R285.5
- 纸质出版日期：2023-04-15，
  
  收稿日期：2022-10-15，
  
  修回日期：2023-03-26，
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梁梦秋,李磊,孟艳秋等.水飞蓟宾防治糖尿病及其并发症的作用机制研究进展 ^Δ[J].中国药房,2023,34(07):887-891.

LIANG Mengqiu,LI Lei,MENG Yanqiu,et al.Research progress on the mechanism of silibinin in preventing and treating diabetes and its complications[J].ZHONGGUO YAOFANG,2023,34(07):887-891.
梁梦秋,李磊,孟艳秋等.水飞蓟宾防治糖尿病及其并发症的作用机制研究进展 ^Δ[J].中国药房,2023,34(07):887-891. DOI： 10.6039/j.issn.1001-0408.2023.07.23.

LIANG Mengqiu,LI Lei,MENG Yanqiu,et al.Research progress on the mechanism of silibinin in preventing and treating diabetes and its complications[J].ZHONGGUO YAOFANG,2023,34(07):887-891. DOI： 10.6039/j.issn.1001-0408.2023.07.23.

摘要

水飞蓟宾是从菊科植物水飞蓟的干燥成熟果实中提取的一种类黄酮，具有多种药理活性，能有效防治糖尿病及其各种并发症。本文对水飞蓟宾防治糖尿病及其并发症的作用机制的研究进展进行综述，发现其能通过上调雌激素受体α表达、激活十二指肠-脑-肝轴通路、稳定蛋白质结构来防治糖尿病；通过激活胰高血糖素样肽-1受体/蛋白激酶A信号通路、抑制tau蛋白过度磷酸化来防治糖尿病神经系统病变；通过下调促炎症、促氧化因子和组蛋白脱乙酰基酶6的表达和活性来防治糖尿病视网膜病变；通过激活蛋白激酶B信号通路和降低转化生长因子β

水平来防治糖尿病肾病；通过抑制肝脏脂质摄取转运体CD36表达和抑制核因子κB通路及其下游促炎细胞因子（肿瘤坏死因子α、白细胞介素1β）表达来防治糖尿病性肥胖，等等。

Abstract

ilibinin is a kind of flavonoid extracted from the dried ripe fruit of

Silybum marianum

，a plant of compositae. It has a variety of pharmacological activities and can effectively prevent and treat diabetes and its complications. This paper reviews the research progress on the mechanism of silibinin in the prevention and treatment of diabetes and its complications. It is found that silibinin can prevent and treat diabetes by up-regulating the expression of estrogen receptor-α，activating the duodenum-brain-liver axis pathway and stabilizing the protein structure. It can prevent and cure the nervous system diseases of diabetes by activating glucagon-like peptide-1 receptor/protein kinase A signal pathway and inhibiting the hyperphosphorylation of tau protein. It can prevent and treat diabetic retinopathy by down-regulating the expression and activity of pro-inflammatory，pro-oxidative factors and histone deacetylase 6. It can prevent diabetic nephropathy by activating protein kinase B signal pathway and reducing the level of transforming growth factor-β

，and prevent and treat diabete’s obesity by inhibition of hepatobiliary transporter CD36 expression，and suppressing nuclear factor-κB pathway and its downstream expression of pro-inflammatory cytokines（tumor necrosis factor-α and interleukin-1β），etc.

关键词

水飞蓟宾糖尿病糖尿病并发症药理靶点作用机制

Keywords

diabetescomplications of diabetespharmacological targetmechanism of action

references

SAEEDI P，PETERSOHN I，SALPEA P，et al. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045：results from the International Diabetes Federation Diabetes Atlas，9th edition[J]. Diabetes Res Clin Pract，2019，157：107843.

邹华杰，余学锋.如何看待磺脲类药物的继发性失效[J].药品评价，2017，14（3）：40-44.

张志鹏，孟艳秋，王趱. 水飞蓟宾及其衍生物生物活性及作用机制的研究进展[J]. 中草药，2021，52（12）：3717-3724.

ZOU H，ZHU X X，ZHANG G B，et al. Silibinin：an old drug for hematological disorders[J]. Oncotarget，2017，8（51）：89307-89314.

CHU C，LI D H，ZHANG S C，et al. Role of silibinin in the management of diabetes mellitus and its complications[J]. Arch Pharm Res，2018，41（8）：785-796.

ANURADHA R，SARASWATI M，KUMAR K G，et al. Apoptosis of beta cells in diabetes mellitus[J]. DNA Cell Biol，2014，33（11）：743-748.

OH Y S，BAE G D，BAEK D J，et al. Fatty acid-induced lipotoxicity in pancreatic beta-cells during development of type 2 diabetes[J]. Front Endocrinol （Lausanne），2018，9：384.

SUN Y，YANG J，LIU W W，et al. Attenuating effect of silibinin on palmitic acid-induced apoptosis and mitochondrial dysfunction in pancreatic β-cells is mediated by estrogen receptor alpha[J]. Mol Cell Biochem，2019，460（1）：81-92.

CHU C，GAO X，LI X，et al. Involvement of estrogen receptor-α in the activation of Nrf2-antioxidative signaling pathways by silibinin in pancreatic β-cells[J]. Biomol Ther （Seoul），2020，28（2）：163-171.

SCARLETT J M，SCHWARTZ M W. Gut-brain mechanisms controlling glucose homeostasis[J]. F1000Prime Rep，2015，7：12.

DUCA F A，CÔTÉ C D，RASMUSSEN B A，et al. Metformin activates a duodenal AMPK-dependent pathway to lower hepatic glucose production in rats[J]. Nat Med，2015，21（5）：506-511.

XU F X，YANG J，NEGISHI H，et al. Silibinin decreases hepatic glucose production through the activation of gut-brain-liver axis in diabetic rats[J]. Food Funct，2018，9（9）：4926-4935.

ARIF B，ASHRAF J M，Moinuddin，et al. Structural and immunological characterization of Amadori-rich human serum albumin：role in diabetes mellitus[J]. Arch Biochem Biophys，2012，522（1）：17-25.

郑晓茂，茹琴，陈琳，等. 晚期糖基化终产物对糖尿病及其并发症的影响和干预的研究进展[J]. 重庆医学，2019，48（13）：2292-2296.

NEELOFAR K，ARIF Z，AHMAD J，et al. Inhibitory effect of silibinin on Amadori-albumin in diabetes mellitus：a multi-spectroscopic and biochemical approach[J]. Spectrochim Acta A Mol Biomol Spectrosc，2019，209：217-222.

RORBACH-DOLATA A，PIWOWAR A. Neurometabolic evidence supporting the hypothesis of increased incidence of type 3 diabetes mellitus in the 21st century[J]. Biomed Res Int，2019，2019：1435276.

VERMA N， LY H， LIU M， et al. Intraneuronal amylin deposition， peroxidative membrane injury and increased IL-1β synthesis in brains of Alzheimer’s disease patients with type-2 diabetes and in diabetic HIP rats[J]. J Alzheimers Dis，2016，53（1）：259-272.

YANG J，SUN Y，XU F X，et al. Silibinin ameliorates amylin-induced pancreatic β-cell apoptosis partly via upregulation of GLP-1R/PKA pathway[J]. Mol Cell Biochem，2019，452（1/2）：83-94.

LIU P W，CUI L Y，LIU B，et al. Silibinin ameliorates STZ-induced impairment of memory and learning by up- regulating insulin signaling pathway and attenuating apoptosis[J]. Physiol Behav，2020，213：112689.

WANG H H，LI Y，LI A，et al. Erratum to：forskolin induces hyperphosphorylation of tau accompanied by cell cycle reactivation in primary hippocampal neurons[J]. Mol Neurobiol，2018，55（1）：707-708.

BARTOLI M，ABOUHISH H，JADEJA R，et al. Anti-senescence properties of the flavone silymarin in the diabetic retina involve direct inhibition of the histone deacetylase 6 （HDAC6）[J]. Investig Ophthalmol Vis Sci，2022，63（7）：4117.

PENG H，SUN Y B，HAO J L，et al. Neuroprotective effects of overexpressed microRNA-200a on activation of glaucoma-related retinal glial cells and apoptosis of ganglion cells via downregulating FGF7-mediated MAPK signaling pathway[J]. Cell Signal，2019，54：179-190.

SHEN Y，ZHAO H X，WANG Z G，et al. Silibinin declines blue light-induced apoptosis and inflammation through MEK/ERK/CREB of retinal ganglion cells[J]. Artif Cells Nanomed Biotechnol，2019，47（1）：4059-4065.

ABRASS C K. Diabetic nephropathy. Mechanisms of mesangial matrix expansion[J]. West J Med，1995，162（4）：318-321.

PATEL R K，MOHAN C. PI3K/AKT signaling and systemic autoimmunity[J]. Immunol Res，2005，31（1）：47-55.

LIU Y，YE J，CAO Y H，et al. Silibinin ameliorates diabetic nephropathy via improving diabetic condition in the mice[J]. Eur J Pharmacol，2019，845：24-31.

张洪江，凃影叶，杜飞，等. TGF-β参与糖尿病肾病的发生发展的机制研究现状[J]. 生命科学，2020，32（2）：179-187.

张传富，路建饶，胡静，等. 水飞蓟宾胶囊治疗早期糖尿病肾病的临床观察[J]. 中医药导报，2017，23（17）：78-80.

GLICK D，BARTH S，MACLEOD K F. Autophagy：cellular and molecular mechanisms[J]. J Pathol，2010，221（1）：3-12.

REZABAKHSH A，FATHI F，BAGHERI H S，et al. Sili- binin protects human endothelial cells from high glucose-induced injury by enhancing autophagic response[J]. J Cell Biochem，2018，119（10）：8084-8094.

MAO Y X，CAI W J，SUN X Y，et al. RAGE-dependent mitochondria pathway：a novel target of silibinin against apoptosis of osteoblastic cells induced by advanced glycation end products[J]. Cell Death Dis，2018，9（6）：674.

ASTRUP A，FINER N. Redefining type 2 diabetes：‘diabesity’ or ‘obesity dependent diabetes mellitus’?[J]. Obes Rev，2000，1（2）：57-59.

ALSAGGAR M，BDOUR S，ABABNEH Q，et al. Sili- binin attenuates adipose tissue inflammation and reverses obesity and its complications in diet-induced obesity model in mice[J]. BMC Pharmacol Toxicol，2020，21（1）：8.

NASTOS C，KALIMERIS K，PAPOUTSIDAKIS N，et al. Global consequences of liver ischemia/reperfusion injury[J]. Oxid Med Cell Longev，2014，2014：906965.

ZHANG R，XU D，ZHANG Y R，et al. Silybin restored CYP3A expression through the sirtuin 2/nuclear factor κ-B pathway in mouse nonalcoholic fatty liver disease[J]. Drug Metab Dispos，2021，49（9）：770-779.

藏赫然. 水飞蓟宾对2型糖尿病合并非酒精性脂肪性肝病患者胰岛素抵抗的影响[D]. 长春：吉林大学，2021.

JUBAIDI F F，ZAINALABIDIN S，TAIB I S，et al. The potential role of flavonoids in ameliorating diabetic cardiomyopathy via alleviation of cardiac oxidative stress，inflammation and apoptosis[J]. Int J Mol Sci，2021，22（10）：5094.

MENG S Y，YANG F，WANG Y Q，et al. Silymarin ameliorates diabetic cardiomyopathy via inhibiting TGF-β1/smad signaling[J]. Cell Biol Int，2019，43（1）：65-72.

YIN S C，MIAO Z F，TAN Y E，et al. SPHK1-induced autophagy in peritoneal mesothelial cell enhances gastric cancer peritoneal dissemination[J]. Cancer Med，2019，8（4）：1731-1743.

AI W，XIE P Y，LING L，et al. Sphk1 involves in the regulation of autophagy process in cardiac myocyte cells at high glucose condition[J/OL]. Researchsquare，2019[2022-09-10]. https：//www.researchgate.net/publication/340208618_Sphk1_involves_in_the_regulation_of_autophagy_process_in_cardiac_myocyte_cells_at_high_glucose_conditionhttps://www.researchgate.net/publication/340208618_Sphk1_involves_in_the_regulation_of_autophagy_process_in_cardiac_myocyte_cells_at_high_glucose_condition. DOI：10.21203/rs.2.11760/v1http://dx.doi.org/10.21203/rs.2.11760/v1.

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