薄荷脑的药理作用及开发应用现状

朱帅鸣; 骆芙瑶; 麻浩; 单俊杰

doi:10.6039/j.issn.1001-0408.2023.13.21

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薄荷脑的药理作用及开发应用现状

综述 | 更新时间：2023-08-15

- 薄荷脑的药理作用及开发应用现状
- Pharmacological effects of menthol and its present development and application
- 中国药房 2023年34卷第13期页码：1651-1655
- 作者机构：
  
  军事科学院军事医学研究院毒物药物研究所，北京　100850
- 作者简介：
  
  助理研究员，博士。研究方向：中药及天然药物化学。电话：010-66874956。E-mail：zhushuaiming@aliyun.com
  研究员。研究方向：中药、天然药物的研究和开发。电话：010-66930644。E-mail：shanjunjie001@126.com
- 基金信息：
  
  国家科技重大专项课题(2018ZX10725-504)
- DOI：10.6039/j.issn.1001-0408.2023.13.21
  中图分类号： R965
- 纸质出版日期：2023-07-15，
  
  收稿日期：2022-10-18，
  
  修回日期：2023-04-25，
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朱帅鸣,骆芙瑶,麻浩等.薄荷脑的药理作用及开发应用现状 ^Δ[J].中国药房,2023,34(13):1651-1655.

ZHU Shuaiming,LUO Fuyao,MA Hao,et al.Pharmacological effects of menthol and its present development and application[J].ZHONGGUO YAOFANG,2023,34(13):1651-1655.
朱帅鸣,骆芙瑶,麻浩等.薄荷脑的药理作用及开发应用现状 ^Δ[J].中国药房,2023,34(13):1651-1655. DOI： 10.6039/j.issn.1001-0408.2023.13.21.

ZHU Shuaiming,LUO Fuyao,MA Hao,et al.Pharmacological effects of menthol and its present development and application[J].ZHONGGUO YAOFANG,2023,34(13):1651-1655. DOI： 10.6039/j.issn.1001-0408.2023.13.21.

摘要

薄荷脑是薄荷挥发油的主要成分，是一种单萜类有机化合物。本文对薄荷脑的药理作用及其在医药领域的开发应用现状进行系统归纳发现，薄荷脑可通过作用于瞬时受体电位（TRP）通道亚家族M成员8、5-羟色胺系统、

-氨基丁酸系统等，保护中枢神经系统；可通过温感调节、缓解热应激压力等调节体温；可通过调控前列腺素E

、白三烯B

等炎症介质的产生和释放，以及TRP通道介导的细胞免疫效应发挥抗炎作用；可通过激活经典痛觉靶点，增强抑制性突触传递等发挥镇痛作用；可通过破坏角质层，促进透皮吸收；可通过调控肿瘤细胞增殖、凋亡和黏附途径等，发挥抗肿瘤作用。薄荷脑既可作为药用辅料，用于药物矫味；也可作为活性成分，在疾病治疗过程中发挥重要药理作用，具有潜在的开发价值。

Abstract

Menthol is the main component of mint volatile oil and a monoterpenoid organic compound. This article systematically summarizes the pharmacological effects， present development and application status of menthol. It is found that menthol can protect the central nervous system through acting on the transient receptor potential （TRP） channel subfamily M member 8， 5-hydroxytryptamine system，

-aminobutyric acid system， etc. Menthol can regulate body temperature through temperature adjustment， relieving heat stress， and other means. It can play an anti-inflammatory role by regulating the production and release of inflammatory mediators such as prostaglandin E

and leukotriene B

， and exert anti-inflammatory effects through cellular immune effect mediated by TRP channel. It can play analgesic role by activating classic pain perception targets and enhancing inhibitory synaptic transmission. It can promote transdermal absorption by destroying the stratum corneum. It can exert anti-tumor effects by regulating tumor cell proliferation， apoptosis， and adhesion pathways. Menthol can be used as a medicinal excipient for correcting the taste of drugs； it can also serve as an active ingredient and play an important pharmacological role in the treatment of disease， with potential development value.

关键词

薄荷脑药理作用开发应用

Keywords

pharmacological effectsdevelopment and application

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