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中药活性成分调控mTOR信号通路干预糖尿病肾病的研究进展
Research progress of active ingredients of traditional Chinese medicine in the intervention of diabetic nephropathy by regulating mTOR signaling pathway
- 中国药房 2023年34卷第13期 页码：1656-1660
- 作者机构：
1.河南中医药大学第一临床医学院，郑州 450046
2.河南中医药大学第一附属医院内分泌科，郑州 450003
- 作者简介：
硕士研究生。研究方向：中医药防治内分泌疾病。 E-mail：j15225125367@163.com
主任医师，硕士生导师。研究方向：中医药防治内分泌疾病。E-mail：13607649136@163.com
- 基金信息：河南省中医药科学研究专项课题(2021ZY2001);河南省首批青苗人才培养项目(豫中医科教〔2018〕16号)
DOI：10.6039/j.issn.1001-0408.2023.13.22
中图分类号： R285纸质出版日期：2023-07-15，
收稿日期：2023-01-02，
修回日期：2023-06-18，
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贾慧雨,冯志海.中药活性成分调控mTOR信号通路干预糖尿病肾病的研究进展 Δ[J].中国药房,2023,34(13):1656-1660.
JIA Huiyu,FENG Zhihai.Research progress of active ingredients of traditional Chinese medicine in the intervention of diabetic nephropathy by regulating mTOR signaling pathway[J].ZHONGGUO YAOFANG,2023,34(13):1656-1660.
贾慧雨,冯志海.中药活性成分调控mTOR信号通路干预糖尿病肾病的研究进展 Δ[J].中国药房,2023,34(13):1656-1660. DOI： 10.6039/j.issn.1001-0408.2023.13.22.
JIA Huiyu,FENG Zhihai.Research progress of active ingredients of traditional Chinese medicine in the intervention of diabetic nephropathy by regulating mTOR signaling pathway[J].ZHONGGUO YAOFANG,2023,34(13):1656-1660. DOI： 10.6039/j.issn.1001-0408.2023.13.22.
摘要
糖尿病肾病（DN）是引起终末期肾病的主要病因之一，发病机制尚不完全清楚，目前认为与高糖条件下自噬紊乱、氧化应激、炎症反应等多种因素介导的肾脏损伤关系密切。哺乳动物雷帕霉素靶蛋白（mTOR）信号通路是参与蛋白质合成及调节自噬过程的核心通路，在DN的发生发展中起着重要作用。近年来，中医药防治DN的研究取得了关键性进展。大量证据表明，中药活性成分可通过调节mTOR信号通路提高自噬水平，改善氧化应激和炎症反应，抑制细胞的凋亡及异常增殖，从而缓解足细胞损伤、肾小球基底膜增厚、系膜组织异常及肾小管功能障碍等肾脏病理改变，减少蛋白尿并改善肾功能，对延缓DN进展具有重要意义。本文系统总结了中药皂苷类、黄酮类、多酚类、生物碱类、萜类等活性成分通过mTOR信号通路干预DN的研究进展，可为进一步的基础研究和临床新药开发提供一定参考。
Abstract
Diabetic nephropathy （DN） has become one of the main causes of end-stage renal disease，and its pathogenesis is still unclear. Currently，it is believed to be closely related to kidney injury mediated by various factors such as autophagy disorder under the condition of high glucose，oxidative stress and inflammation. Mammalian target of rapamycin （mTOR） signaling pathway is crucial for protein synthesis and autophagy regulation，which plays an important role in the occurrence and development of DN. In recent years，the research on the prevention and treatment of DN with traditional Chinese medicine （TCM） has made important progress. Plenty of evidence has shown that the active ingredients of TCM can enhance autophagy，improve oxidative stress and inflammation，inhibit cell apoptosis and abnormal proliferation by regulating mTOR signaling pathway，so as to relieve pathological changes in the kidney such as podocyte injury，glomerular basement membrane thickening，mesangial tissue abnormalities and renal tubule dysfunction，thereby reducing proteinuria and improving renal function. All of the above are of great significance for delaying the progression of DN. This article systematically summarizes the research progress of saponins，flavonoids，polyphenols，alkaloids，terpenoids and other active ingredients of TCM intervening in DN through mTOR signaling pathway，in order to provide some reference for further basic research and the development of new drugs.
关键词
糖尿病肾病中药活性成分哺乳动物雷帕霉素靶蛋白信号通路
Keywords
active ingredients of traditional Chinese medicinemammalian target of rapamycinsignaling pathway
references
中华医学会糖尿病学分会. 中国2型糖尿病防治指南：2020年版[J]. 国际内分泌代谢杂志，2021，41（5）：482-548.
HU Q C，JIANG L，YAN Q，et al. A natural products solution to diabetic nephropathy therapy[J]. Pharmacol Ther，2023，241：108314.
ABOU DAHER A，ALKHANSA S，AZAR W S，et al. Translational aspects of the mammalian target of rapamycin complexes in diabetic nephropathy[J]. Antioxid Redox Signal，2022，37（10/11/12）：802-819.
PUELLES V G，VAN DER WOLDE J W，WANNER N，et al. mTOR-mediated podocyte hypertrophy regulates glomerular integrity in mice and humans[J]. JCI Insight，2019，4（18）：e99271.
NIE Y S，FU C X，ZHANG H M，et al. Celastrol slows the progression of early diabetic nephropathy in rats via the PI3K/AKT pathway[J]. BMC Complement Med Ther，2020，20（1）：321.
CHEN K，YU B，LIAO J. LncRNA SOX2OT alleviates mesangial cell proliferation and fibrosis in diabetic nephropathy via Akt/mTOR-mediated autophagy[J]. Mol Med，2021，27（1）：71.
SONG P N，CHEN Y Y，LIU Z W，et al. LncRNA MALAT1 aggravates renal tubular injury via activating LIN28A and the Nox4/AMPK/mTOR signaling axis in diabetic nephropathy[J]. Front Endocrinol，2022，13：895360.
傅丹青，陈超，侯晓丽，等. 绞股蓝总皂苷对高糖环境下小鼠肾脏足细胞自噬及mTOR/4EBP1/P70S6K信号通路的影响[J]. 中华中医药杂志，2021，36（5）：2499-2502.
韩鹏勋，宋高峰，孙惠力，等. 黄芪甲苷对1型糖尿病STZ小鼠肾组织renalase/Akt/mTOR通路的作用[J]. 广东医学，2018，39（22）：3299-3304.
ZHONG Y J，LUO R L，LIU Q，et al. Jujuboside A ameliorates high fat diet and streptozotocin induced diabetic nephropathy via suppressing oxidative stress，apoptosis，and enhancing autophagy[J]. Food Chem Toxicol，2022，159：112697.
ZHONG Y J，LIU J Y，SUN D J，et al. Dioscin relieves diabetic nephropathy via suppressing oxidative stress and apoptosis，and improving mitochondrial quality and quantity control[J]. Food Funct，2022，13（6）：3660-3673.
张少泉，倪向荣，李鑫辉. 知母皂苷元通过AMPK-mTOR-ULK1途径抑制肾小球系膜基质合成和激活自噬治疗糖尿病肾病的研究[J]. 现代中西医结合杂志，2021，30（11）：1180-1186.
WANG T，GAO Y B，YUE R C，et al. Ginsenoside Rg1 alleviates podocyte injury induced by hyperlipidemia via targeting the mTOR/NF-κB/NLRP3 axis[J]. Evid Based Complement Alternat Med，2020，2020：2735714.
吴浩，符丽珍，赵勇，等. 桔梗皂苷D通过介导PI3K/Akt/mTOR信号通路调节氧化应激改善糖尿病肾病模型大鼠肾损伤[J]. 中国药理学与毒理学杂志，2022，36（3）：170-176.
LIAO J，LIU B，CHEN K，et al. Galangin attenuates oxidative stress-mediated apoptosis in high glucose-induced renal tubular epithelial cells through modulating reni- nangiotensin system and PI3K/AKT/mTOR pathway[J]. Toxicol Res，2021，10（3）：551-560.
GUO L M，TAN K B，LUO Q，et al. Dihydromyricetin promotes autophagy and attenuates renal interstitial fibrosis by regulating miR-155-5p/PTEN signaling in diabetic nephropathy[J]. Bosn J Basic Med Sci，2020，20（3）：372-380.
WANG Y Y，LI Y，ZHANG T，et al. Genistein and Myd88 activate autophagy in high glucose-induced renal podocytes in vitro[J]. Med Sci Monit，2018，24：4823-4831.
LIN W，PAN J，HUANG E J，et al. Ginkgetin alleviates high glucose-evoked mesangial cell oxidative stress injury，inflammation，and extracellular matrix （ECM） deposition in an AMPK/mTOR-mediated autophagy axis[J]. Chem Biol Drug Des，2021，98（4）：620-630.
OU Y，ZHANG W J，CHEN S P，et al. Baicalin improves podocyte injury in rats with diabetic nephropathy by inhi- biting PI3K/Akt/mTOR signaling pathway[J]. Open Med，2021，16（1）：1286-1298.
QIAO S M，LIU R，LV C J，et al. Bergenin impedes the generation of extracellular matrix in glomerular mesangial cells and ameliorates diabetic nephropathy in mice by inhibiting oxidative stress via the mTOR/β-TrcP/Nrf2 pathway[J]. Free Radic Biol Med，2019，145：118-135.
ZHU H P，ZHONG S，YAN H H，et al. Resveratrol reverts streptozotocin-induced diabetic nephropathy[J]. Front Biosci，2020，25（4）：699-709.
WANG X D，GAO L H，LIN H，et al. Mangiferin prevents diabetic nephropathy progression and protects podocyte function via autophagy in diabetic rat glomeruli[J]. Eur J Pharmacol，2018，824：170-178.
韩晓瑜，李嘉斌，丁杰英，等. 姜黄素对糖尿病肾病小鼠肾脏自噬及氧化应激的影响[J]. 中成药，2021，43（6）：1598-1602.
TU Q D，LI Y W，JIN J，et al. Curcumin alleviates diabetic nephropathy via inhibiting podocyte mesenchymal transdifferentiation and inducing autophagy in rats and MPC5 cells[J]. Pharm Biol，2019，57（1）：778-786.
LI C，GUAN X M，WANG R Y，et al. Berberine mitigates high glucose-induced podocyte apoptosis by modulating autophagy via the mTOR/P70S6K/4EBP1 pathway[J]. Life Sci，2020，243：117277.
钟娟，陈静，青姚，等. 川芎嗪通过抑制PI3K/Akt/mTOR通路诱导自噬改善糖尿病肾病大鼠肾损害[J]. 天津医药，2019，47（4）：395-400.
樊小宝，丁通，孙燕，等. 石斛碱对糖尿病肾病大鼠PI3K/Akt/mTOR信号通路及足细胞功能障碍的影响[J]. 河北医药，2021，43（11）：1631-1634，1639.
CHEN Y，LIU Q P，SHAN Z F，et al. Catalpol ameliorates podocyte injury by stabilizing cytoskeleton and enhancing autophagy in diabetic nephropathy[J]. Front Pharmacol，2019，10：1477.
葛文俊，高小坤，毕光宇. 番石榴叶总三萜调控mTOR/S6K1通路减轻糖尿病肾病大鼠肾损害的实验研究[J]. 现代医学，2021，49（11）：1282-1290.
ZHANG X X，JIANG C H，LIU Y，et al. Cyclocarya paliurus triterpenic acids fraction attenuates kidney injury via AMPK-mTOR-regulated autophagy pathway in diabetic rats[J]. Phytomedicine，2019，64：153060.
CHEN J，CUI Y M，ZHANG N，et al. Oleanolic acid attenuated diabetic mesangial cell injury by activation of autophagy via miRNA-142-5p/PTEN signaling[J]. Cytotechnology，2019，71（5）：925-933.
HU Y，WANG S X，WU F Y，et al. Effects and mechanism of Ganoderma lucidum polysaccharides in the treatment of diabetic nephropathy in streptozotocin-induced diabetic rats[J]. Biomed Res Int，2022，2022：4314415.
LV L N，ZHANG J，TIAN F Q，et al. Arbutin protects HK-2 cells against high glucose-induced apoptosis and autophagy by up-regulating microRNA-27a[J]. Artif Cells Nanomed Biotechnol，2019，47（1）：2940-2947.
张筠，丁婷，唐东兴，等. 雷公藤多苷对糖尿病肾病大鼠肾脏细胞自噬的影响及相关机制[J]. 解剖学报，2020，51（3）：373-377.
常帅，徐晓琴，相华，等. 雷公藤多苷通过Akt/mTOR信号通路对糖尿病肾病小鼠肾损伤的影响[J]. 河北医药，2021，43（1）：25-29.
TAO M，ZHENG D N，LIANG X D，et al. Tripterygium glycoside suppresses epithelial‑to‑mesenchymal transition of diabetic kidney disease podocytes by targeting autophagy through the mTOR/Twist1 pathway[J]. Mol Med Rep，2021，24（2）：592.
LIU H，WANG Q，SHI G，et al. Emodin ameliorates renal damage and podocyte injury in a rat model of diabetic nephropathy via regulating AMPK/mTOR-mediated autophagy signaling pathway[J]. Diabetes Metab Syndr Obes，2021，14：1253-1266.
LIU H，CHEN W D，HU Y L，et al. Emodin ameliorates high glucose-induced podocyte apoptosis via regulating AMPK/mTOR-mediated autophagy signaling pathway[J/OL]. Chin J Integr Med，2022（2022-10-11）[2023-06-10]. https：//pubmed.ncbi.nlm.nih.gov/362193831/https://pubmed.ncbi.nlm.nih.gov/362193831/. DOI：10. 1007/s11655-022-3540-9http://dx.doi.org/10.1007/s11655-022-3540-9.
周磊，艾望，陈小娟，等. 萝卜硫素对高糖诱导人肾小管上皮细胞增殖和凋亡的影响及机制[J]. 中国药房，2021，32（24）：3000-3007.
HUANG C，CHENG L J，FENG X Y，et al. Dencichine ameliorates renal injury by improving oxidative stress，apoptosis and fibrosis in diabetic rats[J]. Life Sci，2020，258：118146.
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