复合纳米光疗剂在乳腺癌光疗法中的研究现状与展望

章瑾; 王尚志; 杨明睿; 闫滨

doi:10.6039/j.issn.1001-0408.2023.14.22

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复合纳米光疗剂在乳腺癌光疗法中的研究现状与展望

综述 | 更新时间：2023-07-24

- 复合纳米光疗剂在乳腺癌光疗法中的研究现状与展望
- Current status and prospect of composite nano-phototherapy agents in the phototherapy for breast cancer treatment
- 中国药房 2023年34卷第14期页码：1781-1787
- 作者机构：
  
  1.山东中医药大学药学院，济南　250355
  2.山东中医药大学中医学院，济南　250355
- 作者简介：
  
  硕士研究生。研究方向：中药学和制剂学。E-mail：1719590140@qq.com
  副教授，硕士生导师。研究方向：中药学和制剂学。E-mail：robinyan@163.com
- 基金信息：
  
  国家“重大新药创制”科技重大专项子项目(2014ZX09509001001)
- DOI：10.6039/j.issn.1001-0408.2023.14.22
  中图分类号： R943;R737.9
- 纸质出版日期：2023-07-30，
  
  收稿日期：2023-01-05，
  
  修回日期：2023-06-26，
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章瑾,王尚志,杨明睿等.复合纳米光疗剂在乳腺癌光疗法中的研究现状与展望 ^Δ[J].中国药房,2023,34(14):1781-1787.

ZHANG Jin,WANG Shangzhi,YANG Mingrui,et al.Current status and prospect of composite nano-phototherapy agents in the phototherapy for breast cancer treatment[J].ZHONGGUO YAOFANG,2023,34(14):1781-1787.
章瑾,王尚志,杨明睿等.复合纳米光疗剂在乳腺癌光疗法中的研究现状与展望 ^Δ[J].中国药房,2023,34(14):1781-1787. DOI： 10.6039/j.issn.1001-0408.2023.14.22.

ZHANG Jin,WANG Shangzhi,YANG Mingrui,et al.Current status and prospect of composite nano-phototherapy agents in the phototherapy for breast cancer treatment[J].ZHONGGUO YAOFANG,2023,34(14):1781-1787. DOI： 10.6039/j.issn.1001-0408.2023.14.22.

摘要

光疗法作为一种辅助替代疗法，因非侵入性的诊疗特点广泛用于乳腺癌的早期诊断与后期治疗。但现有光疗剂因疏水性及组织靶向性差、光稳定性低、体内毒副作用明显，限制了其应用范围。随着纳米技术的发展，新型复合纳米光疗剂应运而生。该文总结了近5年新型纳米光疗剂在乳腺癌光疗法中的最新进展，发现随着多功能纳米材料在乳腺癌成像诊疗一体化领域中的发展，经修饰改进后的光疗剂分别在改善光响应以提高光热转换或增加活性氧的生成、靶向肿瘤微环境/免疫细胞/癌细胞表面受体以实现药物的可控响应式释放、利用仿生材料及内源物质改善生物相容性等方面取得了进一步发展。虽然新型光疗剂在转移性乳腺癌模型的治疗中表现出高细胞杀伤率，并能有效抑制其复发转移，但在安全性和协同治疗兼容性等方面仍存在问题。未来研究不仅可以在光疗剂现有作用的基础上加以改进，还可以结合免疫疗法，开发给药途径更便捷的口服药物，以放大免疫反应，多途径协同抵御乳腺癌侵袭。

Abstract

As an adjuvant alternative therapy， phototherapy is widely used for early diagnosis and late treatment of breast cancer due to its non-invasive treatment characteristics. But the application of phototherapeutic agents has been limited in the clinic due to poor hydrophobicity and tissue targeting， low photostability， and obvious toxic side effects

in vivo

. With the development of nanotechnology， new composite nano-phototherapy agents have emerged. This paper summarizes the latest developments and findings of new composite nano-phototherapy agents for phototherapy in the field of breast cancer treatment in the past 5 years. With the development of multifunctional nanomaterials in the field of breast cancer imaging diagnosis and treatment， the modified phototherapy agent achieved further development respectively from improving light response to improve the light thermal conversion or increasing the generation of reactive oxygen species， targeting tumor microenvironment， immune cells and cancer cell surface receptors to achieve drug controllable response release， using biomimetic materials and endogenous substances to improve biocompatibility. Although phototherapeutic agents exhibit high cell-killing rates in the treatment of metastatic breast cancer models and effectively inhibit their recurrence and metastasis， problems remain regarding the safety and compatibility of synergistic therapy. Future studies can not only improve the existing effects of phototherapeutic agents， but also develop oral drugs with more convenient routes based on immunotherapy to amplify the immune response and resist breast cancer through multiple routes.

关键词

光疗剂纳米材料光热治疗光动力治疗乳腺癌

Keywords

nanomaterialsphotothermal therapyphotodynamic therapybreast cancer

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