酵母微囊作为口服药物递送载体的研究进展

刘瑛琪; 李静如; 孟繁; 邢昊楠; 郑爱萍

doi:10.6039/j.issn.1001-0408.2023.16.20

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酵母微囊作为口服药物递送载体的研究进展

综述 | 更新时间：2023-08-24

- 酵母微囊作为口服药物递送载体的研究进展
- Research progress of yeast microcapsules as oral drug delivery carrier
- 中国药房 2023年34卷第16期页码：2022-2027
- 作者机构：
  
  1.华北理工大学药学院，河北唐山　063210
  2.军事医学研究院毒物药物研究所，北京　100850
- 作者简介：
  
  硕士。研究方向：黏膜疫苗。E-mail：1549216916@ qq.com
  研究员，博士。研究方向：纳米技术药物、仿生智能递药系统。电话：010-66931694。E-mail：apzheng@163.com
- 基金信息：
  
  国家自然科学基金资助项目(82104105)
- DOI：10.6039/j.issn.1001-0408.2023.16.20
  中图分类号： R94
- 纸质出版日期：2023-08-30，
  
  收稿日期：2023-04-18，
  
  修回日期：2023-07-26，
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刘瑛琪,李静如,孟繁等.酵母微囊作为口服药物递送载体的研究进展 ^Δ[J].中国药房,2023,34(16):2022-2027.

LIU Yingqi,LI Jingru,MENG Fan,et al.Research progress of yeast microcapsules as oral drug delivery carrier[J].ZHONGGUO YAOFANG,2023,34(16):2022-2027.
刘瑛琪,李静如,孟繁等.酵母微囊作为口服药物递送载体的研究进展 ^Δ[J].中国药房,2023,34(16):2022-2027. DOI： 10.6039/j.issn.1001-0408.2023.16.20.

LIU Yingqi,LI Jingru,MENG Fan,et al.Research progress of yeast microcapsules as oral drug delivery carrier[J].ZHONGGUO YAOFANG,2023,34(16):2022-2027. DOI： 10.6039/j.issn.1001-0408.2023.16.20.

摘要

酵母微囊是一种表面粗糙多孔、核心中空的天然药物递送载体，具有良好的安全性和高靶向性、高稳定性，在口服药物递送系统中具有极佳的应用前景。酵母细胞经过酸碱和有机溶剂处理、洗涤后可获得疏松多孔的酵母微囊，后者可借助静电相互作用、被动扩散、疏水作用等方式包载药物。酵母微囊表面主要由

-葡聚糖组成，可在胃肠环境中保持稳定，可被免疫细胞表面相关受体识别，从而激活免疫反应，并可在被摄取后随淋巴细胞的运动将所载药物运送至病变部位。酵母微囊安全性高，非常适合递送疫苗、抗炎药物及抗肿瘤药物，其不仅可实现上述药物的口服递送，而且能增强药物效果，提高药物的靶向性。今后可开展更多全身转运机制的相关研究或开发更加高效的联合给药系统，以充分发挥酵母微囊的临床价值。

Abstract

As a natural drug delivery carrier with rough and porous surface and hollow core， yeast microcapsules have good safety， high targeting and high stability， and have excellent application prospects in oral drug delivery systems. Yeast cells can be treated and washed with acid-base and organic solvents to obtain loose and porous yeast microcapsules. Yeast microcapsules can encapsulate drugs through electrostatic interactions， passive diffusion， hydrophobic interaction and other methods. The surface of yeast microcapsules is mainly composed of

-glucan， which can maintain stability in the gastrointestinal environment； it can be recognized by the surface-related receptors of immune cells， thus activating the immune response， and can be transported to the lesion site with the movement of lymphocytes after being ingested. Yeast microcapsules are safe and very suitable for delivering vaccines， anti-inflammatory drugs， and anti-tumor drugs. They can not only achieve oral delivery of the aforementioned drugs， but also enhance drug efficacy and improve drug targeting. In the future， more research on systemic transport mechanisms or the development of more efficient combination drug delivery systems can be carried out to fully exhibit the clinical value of yeast microcapsules.

关键词

酵母微囊β-葡聚糖药物递送载体口服药物

Keywords

β-glucandrug delivery carrieroral drug

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