OBJECTIVE

2

To optimize the water extraction process of Maxing kechuan granules.

METHODS

2

With the contents of ephedrine hydrochloride， bergenin， prim-

O

-glucosylcimifugin， 5-

O

-methylvisamin， naringin and hesperidin and the rate of extraction as the evaluation indexes， the weight was determined by the analytic hierarchy process（APH）-entropy weight method， and the comprehensive score was calculated as the response value. Based on the single-factor test， the Box-Behnken response surface method was used to investigate the factors， and the best water extraction process of Maxing kechuan granules was optimized； process validation was also carried out.

RESULTS

2

The best water extraction process of Maxing kechuan granules optimized was as follows： soaking for 40 minutes， adding 8 times water， and extracting for 180 minutes. After three validation tests， the comprehensive score was 94.82 （RSD＝0.96%，

n

＝3）， which had a small difference from the predicted value of 94.64.

CONCLUSIONS

2

The water extraction process of Maxing kechuan granules is stable and reliable， which can provide a reference for the development of the preparation.