浏览全部资源
扫码关注微信
1.中国海洋大学医药学院,山东 青岛 266003
2.青岛妇女儿童医院药学部,山东 青岛 266034
硕士研究生。研究方向:临床药学。E-mail:zxd000324@163.com
主任药师,硕士生导师,硕士。研究方向:医院药事管理、临床药学。E-mail:meixing@163.com
纸质出版日期:2024-01-30,
收稿日期:2023-08-10,
修回日期:2023-11-29,
扫 描 看 全 文
张潇丹,王瑞芹,刘璐等.布拉氏酵母菌对比双歧杆菌三联活菌治疗儿童腹泻有效性和安全性的Meta分析 Δ[J].中国药房,2024,35(02):226-230.
ZHANG Xiaodan,WANG Ruiqin,LIU Lu,et al.Meta-analysis of the efficacy and safety of Saccharomyces boulardii versus Bifidobacterium triple live bacteria in the treatment of pediatric diarrhea[J].ZHONGGUO YAOFANG,2024,35(02):226-230.
张潇丹,王瑞芹,刘璐等.布拉氏酵母菌对比双歧杆菌三联活菌治疗儿童腹泻有效性和安全性的Meta分析 Δ[J].中国药房,2024,35(02):226-230. DOI: 10.6039/j.issn.1001-0408.2024.02.18.
ZHANG Xiaodan,WANG Ruiqin,LIU Lu,et al.Meta-analysis of the efficacy and safety of Saccharomyces boulardii versus Bifidobacterium triple live bacteria in the treatment of pediatric diarrhea[J].ZHONGGUO YAOFANG,2024,35(02):226-230. DOI: 10.6039/j.issn.1001-0408.2024.02.18.
目的
2
比较布拉氏酵母菌与双歧杆菌三联活菌治疗儿童腹泻的有效性和安全性。
方法
2
计算机检索PubMed、Embase、the Cochrane Library、中国生物医学文献数据库、万方数据、中国知网、维普网,收集布拉氏酵母菌(布拉氏组)对比双歧杆菌三联活菌(双歧杆菌组)的随机对照试验(RCT)。筛选文献,提取资料及质量评价后,采用RevMan 5.3软件进行Meta分析。
结果
2
共纳入9项RCT,合计898例患儿。Meta分析结果显示,两组患儿的总有效率[OR=1.69,95%CI(0.93,3.09),
P
=0.09]、腹泻持续时间[MD=-1.39,95%CI(-3.35,0.57),
P
=0.16]、腹痛消失时间[MD=0.09,95%CI(-0.87,1.05),
P
=0.86]、不良反应发生率[OR=0.65,95%CI(0.05,8.03),
P
=0.74]比较,差异均无统计学意义;布拉氏组患儿治疗后大便次数显著少于双歧杆菌组[MD=-0.91,95%CI(-1.80,-0.02),
P
=0.04]。亚组分析结果显示,布拉氏组抗生素相关性腹泻患儿的腹泻持续时间显著少于双歧杆菌组(
P
<0.05)。
结论
2
布拉氏酵母菌与双歧杆菌三联活菌治疗儿童腹泻的疗效和安全性相当,但在治疗后大便次数、抗生素相关性腹泻患儿的腹泻持续时间方面布拉氏酵母菌显著优于双歧杆菌三联活菌。
OBJECTIVE
2
To compare the efficacy and safety of
Saccharomyces boulardii
and Bifidobacterium triple live bacteria in the treatment of pediatric diarrhea.
METHODS
2
Retrieved from PubMed, Embase, the Cochrane Library, CBM, Wanfang data, CNKI and VIP, randomized controlled trials (RCTs) about
S. boulardii
(
S. boulardii
group) versus Bifidobacterium triple liver bacteria (Bifidobacterium group) were collected. After screening the literature, extracting data and evaluating the quality, meta-analysis was performed by using RevMan 5.3 software.
RESULTS
2
A total of 9 RCTs were included, involving 898 patients. Results of meta-analysis showed there was no statistical significance in total response rate [OR=1.69, 95%CI (0.93, 3.09),
P
=0.09], duration of diarrhea [MD=-1.39, 95%CI (-3.35, 0.57),
P
=0.16], the time of abdominal pain disappearance [MD=0.09, 95%CI(-0.87, 1.05),
P
=0.86] or the incidence of adverse reactions [OR=0.65, 95%CI (0.05, 8.03),
P
=0.74]. The number of stools in
S. boulardii
group was significantly less than Bifidobacterium group [MD=-0.91, 95%CI (-1.80, -0.02),
P
=0.04]. The results of subgroup analysis showed that the duration of diarrhea in children with antibiotic-associated diarrhea in
S. boulardii
group was significantly shorter than Bifidobacterium group (
P
<0.05).
CONCLUSIONS
2
The efficacy and safety of
S. boulardii
are similar to those of Bifidobacterium in the treatment of diarrhea, but
S. boulardii
is better than Bifidobacterium in terms of stool number, the duration of diarrhea in children with antibiotic-associated diarrhea.
布拉氏酵母菌双歧杆菌三联活菌儿童腹泻疗效安全性Meta分析
Bifidobacterium triple live bacteriapediatric diarrheaefficacysafetymeta-analysis
罗光全. 小儿腹泻病治疗新进展[J]. 包头医学,2014,38(2):73-76.
LUO G Q. New progress in the treatment of diarrhea in children[J]. J Baotou Med,2014,38(2):73-76.
柳树英,杨志华,原睿,等. 微生态制剂与肠道菌群平衡观在小儿腹泻中的应用[J]. 西部中医药,2014,27(12):94-95.
LIU S Y,YANG Z H,YUAN R,et al. Application of probiotics and intestinal flora balance outlook to infantile diarrhea[J]. West J Tradit Chin Med,2014,27(12):94-95.
王巍,崔立红. 肠道微生态及微生态制剂对腹泻治疗作用的研究进展[J]. 解放军医学院学报,2016,37(7):813-816,819.
WANG W,CUI L H. Advances in intestinal microecology and its therapeutic effect on diarrhea[J]. Acad J Chin PLA Med Sch,2016,37(7):813-816,819.
赵秋霞,陶永明. 布拉酵母菌治疗小儿腹泻的临床探讨[J]. 基层医学论坛,2012,16(23):3017-3018.
ZHAO Q X,TAO Y M. Clinical study on the treatment of infantile diarrhea with Saccharomyces boulardii[J]. Med Forum,2012,16(23):3017-3018.
文静. 儿童腹泻:如何正确使用益生菌[J]. 家庭医药(快乐养生),2022(6):54.
WEN J. Diarrhea in children:how to use probiotics correctly[J]. Home Med,2022(6):54.
张玮娜,李梦甜. 布拉氏酵母菌与双歧杆菌三联活菌治疗儿童腹泻伴发热的疗效观察[J]. 中国妇幼保健,2023,38(5):843-846.
ZHANG W N,LI M T. Clinical observation on the treatment of diarrhea with fever in children with triple viable bacteria of Saccharomyces boulardii and bifidobacterium[J]. Matern Child Health Care China,2023,38(5):843-846.
李晓义,张晓华,张志华,等. 应用布拉酵母菌与双歧杆菌三联活菌治疗儿童轮状病毒性腹泻的疗效对比[J]. 吉林医学,2018,39(2):279-281.
LI X Y,ZHANG X H,ZHANG Z H,et al. The clinical outcome of Saccharomyces boulardii and triple viable bifidobacterium in the treatment of rotaviral gastroenteritis for children[J]. Jilin Med J,2018,39(2):279-281.
胡会,张婷. 儿童腹泻病的诊治策略[J]. 上海医药,2022,43(16):3-6,34.
HU H,ZHANG T. Diagnosis and treatment strategies of diarrhoea in children[J]. Shanghai Med Pharm J,2022,43(16):3-6,34.
ZENG X T,ZHANG Y G,KWONG J S,et al. The metho-dological quality assessment tools for preclinical and clinical studies,systematic review and meta-analysis,and clinical practice guideline:a systematic review[J]. J Evid Based Med,2015,8(1):2-10.
ZHANG J W,WAN S,GUI Q Q. Comparison of safety,effectiveness and serum inflammatory factor indexes of Saccharomyces boulardii versus Bifidobacterium triple viable in treating children with chronic diarrhea:a rando-mized trial[J]. Transl Pediatr,2021,10(6):1677-1685.
刘铁英. 布拉氏酵母菌治疗婴幼儿肺炎继发腹泻的临床研究[J]. 中国保健营养(上旬刊),2014,24(7):3736.
LIU T Y. Brady’s yeast clinical research for the treatment of infantile pneumonia secondary diarrhea[J]. China Health Care Nutr,2014,24(7):3736.
周琴芳. 不同方法治疗支气管肺炎儿童抗生素相关性腹泻的临床分析[J]. 医药前沿,2017,7(12):44-45.
ZHOU Q F. Clinical analysis of different methods in the treatment of antibiotic-associated diarrhea in children with bronchopneumonia[J]. J Front Med,2017,7(12):44-45.
张亚红. 微生态制剂治疗小儿抗生素相关性腹泻的临床观察[J]. 临床医学研究与实践,2017,2(6):116-117.
ZHANG Y H. Clinical observation on the treatment of antibiotic-associated diarrhea in children with microecological preparations[J]. Clin Res Pract,2017,2(6):116-117.
李黎. 小儿消化不良性腹泻采取布拉氏酵母菌散治疗的意义分析[J]. 中国现代药物应用,2020,14(20):141-143.
LI L. Significance of Saccharomyces boulardii sachets in the treatment of children with dyspepsia diarrhea[J]. Chin J Mod Drug Appl,2020,14(20):141-143.
肖智辉,李博. 布拉氏酵母菌联合双歧杆菌三联活菌胶囊治疗儿童病毒性腹泻的疗效观察[J]. 中国全科医学,2013,16(32):3119-3120.
XIAO Z H,LI B. Saccharomyces boulardii combined with bifid-triple viable capsules in children with viral diarrhea[J]. Chin Gen Pract,2013,16(32):3119-3120.
胡艳霞. 布拉酵母菌散与双歧杆菌三联活菌胶囊佐治小儿抗生素相关性腹泻疗效比较[J]. 儿科药学杂志,2014,20(4):22-24.
HU Y X. Efficacy comparison between Saccharomyces boulardii sachets and triple viable bifidobacterium capsule in the treatment of respiratory tract infection with antibiotic-associated diarrhea[J]. J Pediatr Pharm,2014,20(4):22-24.
廖宏,禹教化,段胜稳. 微生态制剂治疗儿童腹泻的疗效及安全性分析[J]. 中国城乡企业卫生,2017,32(6):101-102.
LIAO H,YU J H,DUAN S W. Efficacy and safety analysis of microecological agents in the treatment of children’s diarrhea[J]. Chin J Urban Rural Enterp Hyg,2017,32(6):101-102.
崔玲. 微生态制剂对腹泻患儿临床症状改善及肠道菌群变化的影响[J]. 西藏医药,2017,38(3):7-10.
CUI L. Efficacy of microecological preparation on the changes of intestinal flora and clinical symptoms for children with diarrhea[J]. Tibet Med,2017,38(3):7-10.
左林军. 急性腹泻的常见原因[J]. 家庭生活指南,2023,39(8):193-194.
ZUO L J. Common causes of acute diarrhea[J]. Fam Life Guide,2023,39(8):193-194.
回晶,白琦琦,杨莹,等. 布拉氏酵母菌益生性和功能性的体外评价[J]. 辽宁大学学报(自然科学版),2022,49(4):370-376.
HUI J,BAI Q Q,YANG Y,et al. In vitro evaluation of the probiotic characteristics and function of Saccharomyces cerevisiae boulardii[J]. J Liaoning Univ Nat Sci Ed,2022,49(4):370-376
王忠敏,汤卫红,王惠庭,等. 布拉氏酵母菌散剂治疗抗生素相关性腹泻疗效及对血TNF-α和IL-6水平影响[J]. 浙江中西医结合杂志,2019,29(8):644-646.
WANG Z M,TANG W H,WANG H T,et al. Therapeutic effect of Saccharomyces boulardii powder on antibiotic-associated diarrhea and its influence on serum TNF-α and IL-6 levels[J]. Zhejiang J Integr Tradit Chin West Med,2019,29(8):644-646.
郑月连. 布拉酵母菌辅助治疗小儿轮状病毒性肠炎的疗效观察[J]. 基层医学论坛,2022,26(34):38-40,43.
ZHENG Y L. Clinical observation on the adjuvant treatment of rotavirus enteritis in children with Saccharomyces boulardii[J]. Med Forum,2022,26(34):38-40,43.
0
浏览量
8
下载量
0
CSCD
关联资源
相关文章
相关作者
相关机构