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1.广西医科大学第二附属医院药学部,南宁 530007
2.中日友好医院药学部,北京 100029
主管药师,硕士。研究方向:临床药学、药理学。电话:0771-3393181。E-mail:zongqiang_lai@163.com
主管药师,硕士。研究方向:临床药学。电话:010-84206021。E-mail:wajsyg@163.com
纸质出版日期:2024-01-30,
收稿日期:2023-08-02,
修回日期:2023-12-28,
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赖宗强,李俊,商永光.1例鹦鹉热衣原体重症肺炎患者的抗感染治疗及药学监护 Δ[J].中国药房,2024,35(02):242-246.
LAI Zongqiang,LI Jun,SHANG Yongguang.Anti-infection treatment and pharmaceutical care for a patient with severe pneumonia caused by Chlamydia psittaci[J].ZHONGGUO YAOFANG,2024,35(02):242-246.
赖宗强,李俊,商永光.1例鹦鹉热衣原体重症肺炎患者的抗感染治疗及药学监护 Δ[J].中国药房,2024,35(02):242-246. DOI: 10.6039/j.issn.1001-0408.2024.02.21.
LAI Zongqiang,LI Jun,SHANG Yongguang.Anti-infection treatment and pharmaceutical care for a patient with severe pneumonia caused by Chlamydia psittaci[J].ZHONGGUO YAOFANG,2024,35(02):242-246. DOI: 10.6039/j.issn.1001-0408.2024.02.21.
目的
2
为鹦鹉热衣原体重症肺炎的抗感染药物治疗及药学监护提供思路和用药参考。
方法
2
临床药师参与1例鹦鹉热衣原体重症肺炎患者治疗的全过程,根据患者病史、临床症状、检验结果等情况,协助临床医师动态调整抗感染药物治疗方案:针对鹦鹉热衣原体感染,给予患者替加环素联合阿奇霉素治疗,并结合病原体检查结果对治疗其他感染的用药方案进行动态调整。在治疗过程中,患者出现了QTc间期延长和脂肪酶、淀粉酶升高的可疑药物不良反应,临床药师进行了药学监护并提出合理建议。
结果
2
临床医师采纳临床药师建议,患者经治疗后好转出院。
结论
2
治疗鹦鹉热衣原体重症肺炎,应兼顾患者、药物、病原体三者的特点个性化制定抗感染药物治疗方案。四环素类抗生素和大环内酯类抗生素对鹦鹉热衣原体感染有明确疗效,但是在临床应用中需关注药物可能引起的不良反应。
OBJECTIVE
2
To provide ideas and reference for the anti-infection treatment and pharmaceutical care for severe pneumonia caused by
Chlamydia psittaci
.
METHODS
2
Clinical pharmacists participated in the whole process of the treatment for a patient with
C. psittaci
-induced severe pneumonia. According to the patient’s medical history, clinical symptoms and test results, clinical pharmacists assisted the physician to dynamically adjust the anti-infective scheme; for
C. psittaci
infection, the patient was treated with tigecycline combined with azithromycin successively, and other infection therapy plans were dynamically adjusted according to the results of pathogen examination. During the treatment, the patient suffered from suspicious adverse drug reactions such as prolonged QTc interval, elevated lipase and amylase; the clinical pharmacists conducted pharmaceutical care and put forward reasonable suggestions.
RESULTS
2
The physician adopted the pharmacists’ suggestion, and the patient was discharged after treatment.
CONCLUSIONS
2
For the treatment of severe pneumonia caused by
C. psittaci
, the characteristics of patients, drugs and pathogens should be taken into account to develop individualized anti-infective treatment. Tetracyclines and macrolides have a definite effect on
C. psittaci
infection, but attention should be paid to the possible ADR caused by drugs in clinical application.
鹦鹉热衣原体重症肺炎替加环素阿奇霉素临床药师药学监护
severe pneumoniatigecyclineazithromycinclinical pharmacistpharmaceutical care
ZHANG Z J,ZHOU H,CAO H E,et al. Human-to-human transmission of Chlamydia psittaci in China,2020:an epidemiological and aetiological investigation[J]. Lancet Microbe,2022,3(7):e512-e520.
HOGERWERF L,GIER B D,BAAN B,et al. Chlamydia psittaci(psittacosis)as a cause of community-acquired pneumonia:a systematic review and meta-analysis[J]. Epidemiol Infect,2017,145(15):3096-3105.
WU X D,LI Y Y,ZHANG M,et al. Etiology of severe community-acquired pneumonia in adults based on metagenomic next-generation sequencing:a prospective multicenter study[J]. Infect Dis Ther,2020,9(4):1003-1015.
郭瑛,周燕,杜晓红. 鹦鹉热衣原体重症肺炎1例[J]. 中国感染与化疗杂志,2021,21(2):211-213.
GUO Y,ZHOU Y,DU X H. One case report of severe pneumonia caused by Chlamydia psittaci[J]. Chin J Infect Chemother,2021,21(2):211-213.
LIU J M,GAO Y. Tigecycline in the treatment of severe pneumonia caused by Chlamydia psittaci:a case report and literature review[J]. Front Med,2022,9:1040441.
李洁,祝德秋. 替加环素致多重耐药菌感染患者低纤维蛋白原血症的药学监护[J]. 中国药房,2023,34(8):1010-1013,1024.
LI J,ZHU D Q. The pharmaceutical care of a multidrug-resistant bacterial infection patient with tigecycline-induced hypofibrinogenemia[J]. China Pharm,2023,34(8):1010-1013,1024.
汤夕峰,严永东. 阿奇霉素的临床应用、耐药及不良反应[J]. 国际儿科学杂志,2021,48(2):104-107.
TANG X F,YAN Y D. Clinical application,drug resistance and adverse effects of azithromycin[J]. Int J Pediatr,2021,48(2):104-107.
LU Z M,HOU M L,LI D D,et al. Azithromycin combined with doxycycline in non-gonococcal urethritis[J]. Exp Ther Med,2020,20(4):3887-3894.
KONG C Y,ZHU J,LU J J,et al. Clinical characteristics of Chlamydia psittaci pneumonia[J]. Chin Med J,2021,134(3):353-355.
中华医学会呼吸病学分会. 中国成人社区获得性肺炎诊断和治疗指南:2016年版[J]. 中华结核和呼吸杂志,2016,39(4):253-279.
Chinese Thoracic Society.Guidelines for diagnosis and treatment of adult community-acquired pneumonia in China:2016 edition[J]. Chin J Tuberc Respir Dis,2016,39(4):253-279.
刘丛丛,刘越群. 2例患者因药物致QT间期延长的用药分析[J]. 中南药学,2023,21(10):2813-2816.
LIU C C,LIU Y Q. Drug use analysis of two patients with QT interval prolongation caused by drugs[J]. Cent South Pharm,2023,21(10):2813-2816.
TISDALE J E,CHUNG M K,CAMPBELL K B,et al. Drug-induced arrhythmias:a scientific statement from the American Heart Association[J]. Circulation,2020,142(15):e214-e233.
TISDALE J E,JAYNES H A,KINGERY J R,et al. Develop-ment and validation of a risk score to predict QT interval prolongation in hospitalized patients[J]. Circ Cardiovasc Qual Outcomes,2013,6(4):479-487.
国家药品监督管理局. 国家药监局关于发布个例药品不良反应收集和报告指导原则的通告[EB/OL].(2018-12-19)[2023-08-02]. https://www.nmpa.gov.cn/xxgk/ggtg/ypggtg/ypqtggtg/20181221172901438.htmlhttps://www.nmpa.gov.cn/xxgk/ggtg/ypggtg/ypqtggtg/20181221172901438.html.
National Medical Products Administration.Notice of the National Medical Products Administration on issuing gui-ding principles for collection and reporting of adverse drug reactions in individual cases[EB/OL].(2018-12-19)[2023-08-02]. https://www.nmpa.gov.cn/xxgk/ggtg/ypggtg/ypqtggtg/20181221-172901438.htmlhttps://www.nmpa.gov.cn/xxgk/ggtg/ypggtg/ypqtggtg/20181221-172901438.html.
周煊平,任俊丽,鲁汝淇,等. 替加环素致不良反应的国内外文献分析[J]. 中国医院用药评价与分析,2023,23(2):241-244.
ZHOU X P,REN J L,LU R Q,et al. Domestic and foreign literature of adverse drug reactions induced by tigecycline[J]. Eval Anal Drug Use Hosp China,2023,23(2):241-244.
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