白藜芦醇抗乳腺癌的研究进展

高庆东; 段旭昉; 李妍; 许涛; 于洋洋; 白国栋

doi:10.6039/j.issn.1001-0408.2024.11.22

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白藜芦醇抗乳腺癌的研究进展

综述 | 更新时间：2024-06-11

- 白藜芦醇抗乳腺癌的研究进展
- Research on the role of resveratrol against breast cancer
- 中国药房 2024年35卷第11期页码：1408-1412
- 作者机构：
  
  1.佳木斯市中医医院药剂科，黑龙江佳木斯　154002
  2.佳木斯市向阳区人民医院药剂科，黑龙江佳木斯　154002
  3.黑龙江中医药大学附属第四医院药剂科，哈尔滨　150006
  4.佳木斯市中医医院制剂室，黑龙江佳木斯　154002
- 作者简介：
  
  副主任药师，硕士。研究方向：生药学。E-mail：qingdonggao123@163.com
- 基金信息：
  
  黑龙江省重点研发计划重点领域专项(2022ZXJ03B18)
- DOI：10.6039/j.issn.1001-0408.2024.11.22
  中图分类号： R965
- 纸质出版日期：2024-06-15，
  
  收稿日期：2024-01-23，
  
  修回日期：2024-05-22，
扫描看全文
高庆东,段旭昉,李妍等.白藜芦醇抗乳腺癌的研究进展 ^Δ[J].中国药房,2024,35(11):1408-1412.

GAO Qingdong,DUAN Xufang,LI Yan,et al.Research on the role of resveratrol against breast cancer[J].ZHONGGUO YAOFANG,2024,35(11):1408-1412.
高庆东,段旭昉,李妍等.白藜芦醇抗乳腺癌的研究进展 ^Δ[J].中国药房,2024,35(11):1408-1412. DOI： 10.6039/j.issn.1001-0408.2024.11.22.

GAO Qingdong,DUAN Xufang,LI Yan,et al.Research on the role of resveratrol against breast cancer[J].ZHONGGUO YAOFANG,2024,35(11):1408-1412. DOI： 10.6039/j.issn.1001-0408.2024.11.22.

摘要

乳腺癌的发病率在女性恶性肿瘤中高居榜首，具有侵袭性强、恶性程度高、预后差的特征。白藜芦醇是一种植物抗氧化剂，在对抗乳腺癌发生和发展中具有潜在的多效性。本文通过评估多个体外和体内研究以探索白藜芦醇干预乳腺癌的作用机制，发现白藜芦醇可通过诱导细胞凋亡，调控自噬，抑制糖酵解，调节肿瘤微环境、基质金属蛋白酶、上皮-间质转化、耐药蛋白等的表达，来削弱乳腺癌细胞的增殖和存活能力，抑制乳腺癌细胞的生长、转移和侵袭，逆转乳腺癌细胞对阿霉素的耐药。白藜芦醇的临床试验研究数量有限，主要是关于其对乳腺癌的预防作用，这可能是影响全面评估白藜芦醇抗癌效果的原因之一。

Abstract

Breast cancer （BC） ranks first in the incidence rate of female malignant tumor， the notable features of which include high invasive behavior， high malignant degree and poor prognosis. Resveratrol， a plant antioxidant， has been identified as a potential therapeutic agent for the occurrence and progress of BC. This article explores the mechanism of resveratrol intervention in BC by evaluating several

in vitro

and

in vivo

studies. It was found that resveratrol can weaken the proliferation and survival ability of BC cells， suppress their growth， metastasis， and invasion， and reverse their resistance to adriamycin by promoting cell apoptosis， regulating autophagy， inhibiting glycolysis and regulating the tumor microenvironment， expressions of matrix metalloproteinases， epithelial-mesenchymal transition and drug-resistant proteins， etc. The limited number of clinical trial studies on resveratrol， mainly focusing on prevention effect of it on breast cancer， may be one of the reasons that affect the comprehensive evaluation of the anti-cancer efficacy of resveratrol.

关键词

白藜芦醇乳腺癌细胞凋亡自噬糖酵解肿瘤微环境细胞侵袭细胞转移耐药

Keywords

breast cancercell apoptosisautophagyglycolysistumor microenvironmentcell invasioncell metastasisdrug resistance

references

郑荣寿，陈茹，韩冰峰，等. 2022年中国恶性肿瘤流行情况分析[J]. 中华肿瘤杂志，2024，46（3）：221-231.

ZHENG R S，CHEN R，HAN B F，et al. Analysis on the prevalence of malignant tumors in China in 2022[J]. Chin J Oncol，2024，46（3）：221-231.

NEDELJKOVIĆ M，DAMJANOVIĆ A. Mechanisms of chemotherapy resistance in triple-negative breast cancer：how we can rise to the challenge[J]. Cells，2019，8（9）：957.

WU H，CHEN L，ZHU F F，et al. The cytotoxicity effect of resveratrol：cell cycle arrest and induced apoptosis of breast cancer 4T1 cells[J]. Toxins （Basel），2019，11（12）：731.

SAKAMOTO T，TANIMOTO K，EGUCHI H，et al. Resveratrol exhibits diverse anti-cancer activities through epigenetic regulation of E-cadherin and p21 in triple-negative breast cancer cells[J]. Breast Cancer，2023，30（5）：727-738.

LIANG Z J，WAN Y，ZHU D D，et al. Resveratrol me- diates the apoptosis of triple negative breast cancer cells by reducing POLD1 expression[J]. Front Oncol，2021，11：569295.

AGHAZ F，ASADI Z，SAJADIMAJD S，et al. Codelivery of resveratrol melatonin utilizing pH responsive sericin based nanocarriers inhibits the proliferation of breast cancer cell line at the different pH[J]. Sci Rep，2023，13（1）：11090.

MONDAL A，BENNETT L L. Resveratrol enhances the efficacy of sorafenib mediated apoptosis in human breast cancer MCF7 cells through ROS，cell cycle inhibition，caspase 3 and PARP cleavage[J]. Biomed Pharmacother，2016，84：1906-1914.

WANG J，HUANG P，PAN X F，et al. Resveratrol reverses TGF-β1-mediated invasion and metastasis of breast cancer cells via the SIRT3/AMPK/autophagy signal axis[J]. Phytother Res，2023，37（1）：211-230.

CHENG T T，WANG C，LU Q Q，et al. Metformin inhi- bits the tumor-promoting effect of low-dose resveratrol，and enhances the anti-tumor activity of high-dose resveratrol by increasing its reducibility in triple negative breast cancer[J]. Free Radical Bio Med，2022，180：108-120.

VERA-RAMIREZ L，VODNALA S K，NINI R，et al. Autophagy promotes the survival of dormant breast cancer cells and metastatic tumour recurrence[J]. Nat Commun，2018，9（1）：1944.

ALAYEV A，BERGER S M，KRAMER M Y，et al. The combination of rapamycin and resveratrol blocks autophagy and induces apoptosis in breast cancer cells[J]. J Cell Biochem，2015，116（3）：450-457.

KIM N H，SUNG N J，YOUN H S，et al. Gremlin-1 activates Akt/STAT3 signaling，which increases the glycolysis rate in breast cancer cells[J]. Biochem Biophys Res Commun，2020，533（4）：1378-1384.

GOMEZ L S，ZANCAN P，MARCONDES M C，et al. Resveratrol decreases breast cancer cell viability and glucose metabolism by inhibiting 6-phosphofructo-1-kinase[J]. Biochimie，2013，95（6）：1336-1343.

HAN X，ZHAO N，ZHU W W，et al. Resveratrol atte- nuates TNBC lung metastasis by down-regulating PD-1 expression on pulmonary T cells and converting macrophages to M1 phenotype in a murine tumor model[J]. Cell Immunol，2021，368：104423.

SICA A，MANTOVANI A. Macrophage plasticity and polarization：in vivo veritas[J]. J Clin Invest，2012，122（3）：787-795.

CHEUK I W，CHEN J，SIU M，et al. Resveratrol enhanced chemosensitivity by reversing macrophage polari- zation in breast cancer[J]. Clin Transl Oncol，2022，24（5）：854-863.

LI C C，XU Y J，ZHANG J F，et al. The effect of resveratrol，curcumin and quercetin combination on immuno-suppression of tumor microenvironment for breast tumor-bearing mice[J]. Sci Rep，2023，13（1）：13278.

PISKÓR B M，PRZYLIPIAK A，DĄBROWSKA E，et al. Plasma level of MMP-10 may be a prognostic marker in early stages of breast cancer[J]. J Clin Med，2020，9（12）：4122.

SHUNMUGA PRIYA V，PRADIBA D，AARTHY M，et al. In-silico strategies for identification of potent inhibitor for MMP-1 to prevent metastasis of breast cancer[J]. J Biomol Struct Dyn，2021，39（18）：7274-7293.

OZKAN E，BAKAR-ATES F. Potentiation of the effect of lonidamine by quercetin in MCF-7 human breast cancer cells through downregulation of MMP-2/9 mRNA expression[J]. An Acad Bras Cienc，2020，92（4）：e20200548.

ZHANG K J，LIU X L，HAO F Y，et al. Targeting TGF-β1 inhibits invasion of anaplastic thyroid carcinoma cell through SMAD2-dependent S100A4-MMP-2/9 signalling[J]. Am J Transl Res，2016，8（5）：2196-2209.

JIANG L Y，XIE X，BI R，et al. Knockdown of Linc00511 inhibits TGF-β-induced cell migration and invasion by suppressing epithelial-mesenchymal transition and down-regulating MMPs expression[J]. Biomed Pharmacother，2020，125：109049.

SUN Y，ZHOU Q M，LU Y Y，et al. Resveratrol inhibits the migration and metastasis of MDA-MB-231 human breast cancer by reversing TGF-β1-induced epithelial-mesenchymal transition[J]. Molecules，2019，24（6）：1131.

YANG M D，SUN Y，ZHOU W J，et al. Resveratrol enhances inhibition effects of cisplatin on cell migration and invasion and tumor growth in breast cancer MDA-MB-231 cell models in vivo and in vitro[J]. Molecules，2021，26（8）：2204.

ZHANG W，JIANG H T，CHEN Y J，et al. Resveratrol chemosensitizes adriamycin-resistant breast cancer cells by modulating miR-122-5p[J]. J Cell Biochem，2019，120（9）：16283-16292.

梁睿，翟溯澜，王柳燕，等. 白藜芦醇调控miR-519c逆转乳腺癌多柔比星耐药作用机制研究[J]. 中华肿瘤防治杂志，2019，26（15）：1066-1071.

LIANG R，ZHAI S L，WANG L Y，et al. Effect and mechanisms of resveratrol reversing breast cancer cells’ doxorubicin resistance by regulating and controlling miR-519c[J]. Chin J Cancer Prev Treat，2019，26（15）：1066-1071.

JIN X X，WEI Y Z，LIU Y S，et al. Resveratrol promotes sensitization to doxorubicin by inhibiting epithelial-mesenchymal transition and modulating SIRT1/β-catenin signaling pathway in breast cancer[J]. Cancer Med，2019，8（3）：1246-1257.

KOMOROWSKA D，GAJEWSKA A，HIKISZ P，et al. Comparison of the effects of resveratrol and its derivatives on the radiation response of MCF-7 breast cancer cells[J]. Int J Mol Sci，2021，22（17）：9511.

AGHAMIRI S，JAFARPOUR A，ZANDSALIMI F，et al. Effect of resveratrol on the radiosensitivity of 5-FU in human breast cancer MCF-7 cells[J]. J Cell Biochem，2019，120（9）：15671-15677.

DA COSTA ARALDI I C，BORDIN F P R，CADONÁ F C，et al. The in vitro radiosensitizer potential of resveratrol on MCF-7 breast cancer cells[J]. Chem Biol Interact，2018，282：85-92.

BROWN V A，PATEL K R，VISKADURAKI M，et al. Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers：safety，pharmacokinetics，and effect on the insulin-like growth factor axis[J]. Cancer Res，2010，70（22）：9003-9011.

ZHU W Z，QIN W Y，ZHANG K，et al. Trans-resveratrol alters mammary promoter hypermethylation in women at increased risk for breast cancer[J]. Nutr Cancer，2012，64（3）：393-400.

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