浏览全部资源
扫码关注微信
中药通过PI3K/Akt信号通路干预肾间质纤维化的研究进展
Research progress on the intervention of traditional Chinese medicine in renal interstitial fibrosis based on PI3K/Akt signaling pathway
- 中国药房 2024年35卷第14期 页码：1795-1800
- 作者机构：
1.齐齐哈尔医学院基础医学院，黑龙江 齐齐哈尔 161006
2.黑龙江省药食同源资源与代谢性疾病防治重点实验室，黑龙江 齐齐哈尔 161006
3.齐齐哈尔医学院公共卫生学院，黑龙江 齐齐哈尔 161006
4.齐齐哈尔医学院口腔医学院，黑龙江 齐齐哈尔 161006
5.齐齐哈尔医学院医学技术学院，黑龙江 齐齐哈尔 161006
6.齐齐哈尔医学院药学院，黑龙江 齐齐哈尔 161006
- 作者简介：
讲师，硕士生导师，博士。研究方向：肾间质纤维化、高血压肾损伤、肾小管上皮细胞离子转运。E-mail：lixue_0720@163.com
- 基金信息：国家级大学生创新创业训练计划项目(202311230035);黑龙江省自然科学基金项目(LH2021H120);齐齐哈尔医学科学院青年博士项目(QMSI2022B-03);齐齐哈尔医学科学院博士滚动支持项目(QMSI2023E-02);齐齐哈尔医学科学院重点培育项目(2024-ZDPY-002)
DOI：10.6039/j.issn.1001-0408.2024.14.22
中图分类号： R965;R285.5纸质出版日期：2024-07-30，
收稿日期：2024-01-20，
修回日期：2024-06-18，
- 稿件说明：
扫 描 看 全 文
李雪,张云龙,宋子毅等.中药通过PI3K/Akt信号通路干预肾间质纤维化的研究进展 Δ[J].中国药房,2024,35(14):1795-1800.
LI Xue,ZHANG Yunlong,SONG Ziyi,et al.Research progress on the intervention of traditional Chinese medicine in renal interstitial fibrosis based on PI3K/Akt signaling pathway[J].ZHONGGUO YAOFANG,2024,35(14):1795-1800.
李雪,张云龙,宋子毅等.中药通过PI3K/Akt信号通路干预肾间质纤维化的研究进展 Δ[J].中国药房,2024,35(14):1795-1800. DOI： 10.6039/j.issn.1001-0408.2024.14.22.
LI Xue,ZHANG Yunlong,SONG Ziyi,et al.Research progress on the intervention of traditional Chinese medicine in renal interstitial fibrosis based on PI3K/Akt signaling pathway[J].ZHONGGUO YAOFANG,2024,35(14):1795-1800. DOI： 10.6039/j.issn.1001-0408.2024.14.22.
摘要
肾间质纤维化（RIF）是慢性肾病的主要病理表现结果，由于其发生机制复杂，临床上尚无特效治疗措施。磷脂酰肌醇3-激酶（PI3K）/蛋白激酶B（Akt）信号通路的异常激活及其下游靶基因的活化是RIF发生进展的关键诱因。中药具有药效确切、毒副作用小等特点，可多靶点、多途径协同调控RIF的发生进展。本文以PI3K/Akt信号通路为核心，对中药在RIF治疗中的作用靶点及调控机制进行归纳，发现多种中药有效成分（如青藤碱、芒果苷、圆锥绣球提取物等）以及复方（如复肾功方、气邦益肾方等）可通过该通路抑制成纤维细胞增殖、改善炎症反应与氧化应激、维持线粒体稳态、减缓铁死亡发生等，从而延缓RIF的发生进展。
Abstract
Renal
interstitial fibrosis（RIF） is the main pathological manifestation of chronic kidney disease. Due to the complexity of the mechanism， there is no specific treatment for RIF in clinical practice. The abnormal activation of the phosphatidylinositol 3-kinase （PI3K）/protein kinase B（Akt） signaling pathway and the activation of downstream target genes are key drivers of RIF induction and progression. Traditional Chinese medicine has the characteristics of precise efficacy and minimal toxic side effects， and the occurrence and development of RIF can be regulated by multiple targets and mutual coordination. This review focuses on the PI3K/Akt signaling pathway and summarizes the potential targets and regulatory mechanisms of traditional Chinese medicine in the treatment of RIF. It is found that various effective ingredients （such as sinomenine， mangiferin， coumarin derivates from
Hydrangea paniculata
， etc.） and formulas （such as Fushengong decoction， Qi-Bang-Yi-Shen formula， etc.） of traditional Chinese medicine can inhibit fibroblast proliferation， improve inflammation and oxidative stress， maintain mitochondrial stability， and slow down ferroptosis through this pathway， thereby delaying the occurrence and progression of RIF.
关键词
中药PI3K/Akt信号通路肾间质纤维化作用机制
Keywords
PI3K/Akt signaling pathwayrenal interstitial fibrosisaction of mechanism
references
LIU J，YANG F，WAHEED Y，et al. The role of roxadustat in chronic kidney disease patients complicated with anemia[J]. Korean J Intern Med，2023，38（2）：147-156.
ZHANG L X，WANG F，WANG L，et al. Prevalence of chronic kidney disease in China：a cross-sectional survey[J]. Lancet，2012，379（9818）：815-822.
WEBSTER A C，NAGLER E V，MORTON R L，et al. Chronic kidney disease[J]. Lancet，2017，389（10075）：1238-1252.
BREYER M D，BÖTTINGER E，3rdBROSIUS F C，et al. Mouse models of diabetic nephropathy[J]. J Am Soc Nephrol，2005，16（1）：27-45.
THURLOW J S，JOSHI M，YAN G F，et al. Global epidemiology of end-stage kidney disease and disparities in kidney replacement therapy[J]. Am J Nephrol，2021，52（2）：98-107.
FRUMAN D A，CHIU H，HOPKINS B D，et al. The PI3K pathway in human disease[J]. Cell，2017，170（4）：605-635.
RODRÍGUEZ-PEÑA A B，GRANDE M T，ELENO N，et al. Activation of ERK1/2 and Akt following unilateral ureteral obstruction[J]. Kidney Int，2008，74（2）：196-209.
ZHOU T，LUO M，CAI W，et al. Runt-related transcription factor 1（RUNX1）promotes TGF-β-induced renal tubular epithelial-to-mesenchymal transition（EMT）and renal fibrosis through the PI3K subunit p110δ[J]. EBioMedicine，2018，31：217-225.
KIM I Y，PARK Y K，SONG S H，et al. Role of Akt1 in renal fibrosis and tubular dedifferentiation during the progression of acute kidney injury to chronic kidney disease[J]. Korean J Intern Med，2021，36（4）：962-974.
HUANG X J，LIU G H，GUO J，et al. The PI3K/Akt pathway in obesity and type 2 diabetes[J]. Int J Biol Sci，2018，14（11）：1483-1496.
YU L，BORDER W A，HUANG Y F，et al. TGF-beta isoforms in renal fibrogenesis[J]. Kidney Int，2003，64（3）：844-856.
NISHIMURA K，TAGUCHI K，KISHI S，et al. Dual disruption of eNOS and ApoE gene accelerates kidney fibrosis and senescence after injury[J]. Biochem Biophys Res Commun，2021，556：142-148.
HU T T，CHEN F，CHEN D，et al. DNMT3a negatively regulates PTEN to activate the PI3K/Akt pathway to aggravate renal fibrosis[J]. Cell Signal，2022，96：110352.
AN C L，JIAO B H，DU H，et al. Myeloid PTEN deficiency aggravates renal inflammation and fibrosis in angiotensin Ⅱ-induced hypertension[J]. J Cell Physiol，2022，237（1）：983-991.
SAMARAKOON R，HELO S，DOBBERFUHL A D，et al. Loss of tumour suppressor PTEN expression in renal injury initiates SMAD3- and p53-dependent fibrotic responses[J]. J Pathol，2015，236（4）：421-432.
AKAMO A J，ROTIMI S O，AKINLOYE D I，et al. Naringin prevents cyclophosphamide-induced hepatotoxicity in rats by attenuating oxidative stress，fibrosis，and inflammation[J]. Food Chem Toxicol，2021，153：112266.
SHI H H，ZHANG L Y，CHEN L P，et al. EPA-enriched phospholipids alleviate renal interstitial fibrosis in spontaneously hypertensive rats by regulating TGF-β signaling pathways[J]. Mar Drugs，2022，20（2）：152.
YANG F，ZHANG Y Y，DONG L，et al. Cordyceps cicadae ameliorates inflammatory responses，oxidative stress，and fibrosis by targeting the PI3K/mTOR-mediated autophagy pathway in the renal of MRL/LPR mice[J]. Immun Inflamm Dis，2024，12（1）：e1168.
YAO L，LIANG X H，LIU Y M，et al. Non-steroidal mi-neralocorticoid receptor antagonist finerenone ameliorates mitochondrial dysfunction via PI3K/Akt/eNOS signaling pathway in diabetic tubulopathy[J]. Redox Biol，2023，68：102946.
刘晓羽，黄志敏，邱少彬，等. 三七调节肾脏PI3K/Akt/mTORC1-线粒体能量代谢治疗血瘀证慢性肾衰竭大鼠的机制研究[J]. 中国中药杂志，2024，49（7）：1888-1895.
LIU X Y，HUANG Z M，QIU S B，et al. Mechanism of Notoginseng radix et rhizoma in regulating PI3K/Akt/mTORC1-mitochondrial energy metabolism to treat chronic renal failure in rats with blood stasis syndrome[J]. China J Chin Mater Med，2024，49（7）：1888-1895.
LIU Y，WANG J Y. Ferroptosis，a rising force against renal fibrosis[J]. Oxid Med Cell Longev，2022，2022：7686956.
邱莎，杨丽，谭睿陟，等. 黄柏酮对单侧输尿管梗阻模型小鼠肾间质纤维化及铁死亡的影响[J]. 中国药房，2023，34（5）：554-559.
QIU S，YANG L，TAN R Z，et al. Effects of obacunone on renal interstitial fibrosis and ferroptosis in unilateral ureteral obstruction model mice[J]. China Pharm，2023，34（5）：554-559.
HAO J L，ZHANG W Q，HUANG Z Q. Bupivacaine modulates the apoptosis and ferroptosis in bladder cancer via phosphatidylinositol 3-kinase（PI3K）/Akt pathway[J]. Bioengineered，2022，13（3）：6794-6806.
LI X，ZOU Y，XING J，et al. Pretreatment with roxadustat（FG-4592）attenuates folic acid-induced kidney injury through antiferroptosis via Akt/GSK-3β/Nrf2 pathway[J]. Oxid Med Cell Longev，2020，2020：6286984.
WANG Z H，CHEN Z，LI B S，et al. Curcumin attenuates renal interstitial fibrosis of obstructive nephropathy by suppressing epithelial-mesenchymal transition through inhibition of the TLR4/NF-κB and PI3K/Akt signalling pathways[J]. Pharm Biol，2020，58（1）：828-837.
GU H P，LI J R，NI Y H. Sinomenine improves renal fibrosis by regulating mesenchymal stem cell-derived exosomes and affecting autophagy levels[J]. Environ Toxicol，2023，38（10）：2524-2537.
DOU F，LIU Y T，LIU L M，et al. Aloe-emodin ameliorates renal fibrosis via inhibiting PI3K/Akt/mTOR signa-ling pathway in vivo and in vitro[J]. Rejuvenation Res，2019，22（3）：218-229.
SONG Y Y，LIU W，TANG K，et al. Mangiferin alleviates renal interstitial fibrosis in streptozotocin-induced diabetic mice through regulating the PTEN/PI3K/Akt signaling pathway[J]. J Diabetes Res，2020，2020：9481720.
TU H T，MA D H，LUO Y Y，et al. Quercetin alleviates chronic renal failure by targeting the PI3K/Akt pathway[J]. Bioengineered，2021，12（1）：6538-6558.
ZHONG Y N，LI X，XIE J，et al. Network pharmacology combined with molecular docking and experimental validation to reveal the pharmacological mechanism of naringin against renal fibrosis[J]. Open Med（Wars），2023，18（1）：20230736.
LI X Y，HUANG X，FENG Y M，et al. Cylindrin from Imperata cylindrica inhibits M2 macrophage formation and attenuates renal fibrosis by downregulating the LXR-α/PI3K/Akt pathway[J]. Eur J Pharmacol，2023，950：175771.
WANG W D，SHENG L，CHEN Y Y，et al. Total coumarin derivates from Hydrangea paniculata attenuate renal injuries in cationized-BSA induced membranous nephropathy by inhibiting complement activation and interleukin 10-mediated interstitial fibrosis[J]. Phytomedicine，2022，96：153886.
LI R，SHI C R，WEI C T，et al. Fufang Shenhua tablet inhibits renal fibrosis by inhibiting PI3K/Akt[J]. Phytomedicine，2023，116：154873.
YUAN H，WU X L，WANG X M，et al. Chinese herbal decoction astragalus and angelica exerts its therapeutic effect on renal interstitial fibrosis through the inhibition of MAPK，PI3K-Akt and TNF signaling pathways[J]. Genes Dis，2022，9（2）：510-521.
LUO H Y，WANG M N，XU K，et al. Effect of Fushengong decoction on PTEN/PI3K/Akt/NF-κB pathway in rats with chronic renal failure via dual-dimension network pharmacology strategy[J]. Front Pharmacol，2022，13：807651.
WANG Z，JIAN G H，CHEN T，et al. The Qi-Bang-Yi-Shen formula ameliorates renal dysfunction and fibrosis in rats with diabetic kidney disease via regulating PI3K/Akt，ERK and PPARγ signaling pathways[J]. Eur J Histochem，2023，67（1）：3648.
FAN Z L，CHEN J J，YANG Q R，et al. Network pharmacology and experimental validation to reveal the pharmacological mechanisms of chongcaoyishen decoction against chronic kidney disease[J]. Front Mol Biosci，2022，9：847812.
李荣荣，马华，田树杰，等. 芪红通瘀饮对肾间质纤维化大鼠肾组织Wnt/β-catenin信号通路的影响[J]. 中华中医药杂志，2020，35（4）：1755-1759.
LI R R，MA H，TIAN S J，et al. Effects of Qihong tongyu decoction on Wnt/β-catenin signaling pathway in renal tissue of rats with renal interstitial fibrosis[J]. China J Tradit Chin Med Pharm，2020，35（4）：1755-1759.
0
浏览量
0
下载量
0
CSCD
- 网络PDF下载
- WORD下载
- Meta-XML下载
- BibTeX下载
- Endnote下载
- RefMan 下载
- NoteExpress下载
- NoteFirst下载
关联资源
相关文章
相关作者
相关机构
- 地址：重庆市渝中区大坪正街129号四环大厦8层 邮编：400042
- 技术支持由北京北大方正电子有限公司提供 渝ICP备15012710号
公网安备50010302001817 - 本系统建议在Chrome、 IE9+ 以上版本浏览器阅读本站内容，360浏览器请切换至极速模式
- Cookies帮助我们提供服务并提供个性化体验。使用本网站，即表示您同意我们使用Cookies